The associations between maternal and child diet quality and child ADHD - findings from a large Norwegian pregnancy cohort study

被引：31

作者：

Borge, Tiril Cecilie ^{[1
]}

Biele, Guido ^{[1
]}

Papadopoulou, Eleni ^{[2
]}

Andersen, Lene Frost ^{[3
]}

Jacka, Felice ^{[4
,5
,6
,7
]}

Eggesbo, Merete ^{[2
]}

Caspersen, Ida Henriette ^{[2
]}

Aase, Heidi ^{[1
]}

Meltzer, Helle Margrete ^{[8
]}

Brantsaeter, Anne Lise ^{[2
]}

机构：

[1] Norwegian Inst Publ Hlth, Dept Child Hlth & Dev, POB 222, N-0213 Oslo, Norway

[2] Norwegian Inst Publ Hlth, Dept Environm Hlth, Sect Environm Exposure & Epidemiol, POB 222, N-0213 Oslo, Norway

[3] Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway

[4] Deakin Univ, Food & Mood Ctr, IMPACT, Geelong, Vic, Australia

[5] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Parkville, Vic, Australia

[6] Black Dog Inst, Randwick, NSW, Australia

[7] James Cook Univ, Townsville, Qld, Australia

[8] Norwegian Inst Publ Hlth, Div Infect Control & Environm Hlth, POB 222, N-0213 Oslo, Norway

来源：

BMC PSYCHIATRY | 2021年 / 21卷 / 01期

基金：

芬兰科学院;

关键词：

MoBa; Maternal diet quality; Child diet quality; Child ADHD; Bayesian modelling; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SELF-REPORT; MOTHER; WOMEN; BIAS; VALIDITY; HEALTH; GUIDELINES; NUTRITION; COGNITION;

D O I：

10.1186/s12888-021-03130-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder. Effective long-term treatment options are limited, which warrants increased focus on potential modifiable risk factors. The aim of this study was to investigate associations between maternal diet quality during pregnancy and child diet quality and child ADHD symptoms and ADHD diagnosis.MethodsThis study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa). We assessed maternal diet quality with the Prenatal Diet Quality Index (PDQI) and Ultra-Processed Food Index (UPFI) around mid-gestation, and child diet quality using the Diet Quality Index (CDQI) at 3years. ADHD symptoms were assessed at child age 8years using the Parent Rating Scale for Disruptive Behaviour Disorders. ADHD diagnoses were retrieved from the Norwegian Patient Registry.ResultsIn total, 77,768 mother-child pairs were eligible for studying ADHD diagnoses and 37,787 for ADHD symptoms. Means (SD) for the PDQI, UPFI and CDQI were 83.1 (9.3), 31.8 (9.7) and 60.3 (10.6), respectively. Mean (SD) ADHD symptom score was 8.4 (7.1) and ADHD diagnosis prevalence was 2.9% (male to female ratio 2.6:1). For one SD increase in maternal diet index scores, we saw a change in mean (percent) ADHD symptom score of -0.28 (-3.3%) (CI: -0.41, -0.14 (-4.8, -1.6%)) for PDQI scores and 0.25 (+3.0%) (CI: 0.13, 0.38 (1.5, 4.5%)) for UPFI scores. A one SD increase in PDQI score was associated with a relative risk of ADHD diagnosis of 0.87 (CI: 0.79, 0.97). We found no reliable associations with either outcomes for the CDQI, and no reliable change in risk of ADHD diagnosis for the UPFI.ConclusionsWe provide evidence that overall maternal diet quality during pregnancy is associated with a small decrease in ADHD symptom score at 8years and lower risk for ADHD diagnosis, with more robust findings for the latter outcome. Consumption of ultra-processed foods was only associated with increased ADHD symptom score of similar magnitude as for overall maternal diet quality, and we found no associations between child diet quality and either outcome. No causal inferences should be made based on these results, due to potential unmeasured confounding.

引用

页数：14

共 82 条

[1] Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study [J].