Optimization of the delivery of molecules into lymph nodes using a lymphatic drug delivery system with ultrasound

被引:3
作者
Kato, Shigeki [1 ,2 ,3 ]
Yoshiba, Shota [1 ,2 ]
Mori, Shiro [1 ,2 ,4 ]
Kodama, Tetsuya [1 ,2 ,5 ]
机构
[1] Tohoku Univ, Dept Biomed Engn, Lab Biomed Engn Canc, Grad Sch Biomed Engn, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Biomed Engn Canc Res Ctr, Grad Sch Biomed Engn, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan
[3] Kindai Univ, Dept Immunol, Fac Med, Osaka, Osaka 5898511, Japan
[4] Tohoku Univ Hosp, Dept Oral & Maxillofacial Surg, Aoba Ku, 1-1 Seiryo, Sendai, Miyagi 9808575, Japan
[5] Tohoku Univ, Grad Sch Engn, Dept Elect Engn, Aoba Ku, 4-1 Seiryo, Sendai, Miyagi 9808575, Japan
关键词
Lymph node metastasis; Ultrasound; Drug delivery; Chemotherapy; Lymphatic vessel; Acoustic liposome;
D O I
10.1016/j.ijpharm.2021.120324
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Conventional treatment for lymph node (LN) metastasis such as systemic chemotherapy have notable disadvantages that lead to the development of unwanted effects. Previously, we have reported the lymphatic administration of drugs into metastatic LNs using a lymphatic drug delivery system (LDDS). However, prior studies of the LDDS have not attempted to optimize the conditions for efficient drug delivery. Here, we investigated the influence of several factors on the efficiency of drug delivery by a LDDS in conjunction with ultrasound (US). First, the effect of the injection rate on delivery efficiency was evaluated. Fluorescent molecules injected into an upstream LN were delivered more effectively into a downstream LN when a lower injection rate was used. Second, the influence of molecular weight on drug delivery efficiency was determined. We found that molecules with a molecular weight >10,000 were poorly delivered into the LN. Finally, we assessed whether the administration route affected the delivery efficiency. We found that the delivery efficiency was higher when molecules were administered into an upstream LN that was close to the target LN. These findings revealed the importance of a drug's physical properties if it is to be administered by LDDS to treat LN metastasis.
引用
收藏
页数:8
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