Role of proton receptor OGR1 in bone response to metabolic acidosis?

被引：10

作者：

Jorgetti, Vanda ^{[1
]}

Drueeke, Tilman B. ^{[2
,3
]}

Ott, Susan M. ^{[4
]}

机构：

[1] Univ Sao Paulo, Dept Internal Med, Div Nephrol, Sao Paulo, Brazil

[2] Univ Paris Sud, Hop Paul Brousse, Inserm,Unit 1018, Ctr Rech Epidemiol & Sante Populat CESP,Team 5, Villejuif, France

[3] Paris Ile De France Ouest Univ, Versailles St Quentin En Yvelines Univ, Villejuif, France

[4] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

KIDNEY INTERNATIONAL | 2016年 / 89卷 / 03期

关键词：

EXPRESSION;

D O I：

10.1016/j.kint.2015.12.031

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic metabolic acidosis stimulates bone resorption, resulting in loss of calcium and bicarbonate from bone. Both osteoblasts and osteoclasts sense extracellular H+ by the G-protein coupled receptor, OGR1, whose activation leads to increased bone resorption as well as decreased bone formation. Krieger et al. examined the effect of OGR1 knockout in mice. They found an unexpected increase in bone resorption, but nevertheless an increase in bone volume linked to enhanced bone formation. This discovery opens a window of opportunity to explore potential new anabolic treatments for patients with low bone mass. (C) 2016 International Society of Nephrology

引用

页码：529 / 531

页数：3

共 9 条

[1] Serum Bicarbonate and Bone Mineral Density in US Adults [J].

Chen, Wei ;

Melamed, Michal L. ;

Abramowitz, Matthew K. .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2015, 65 (02) :240-248

[2] Promotion of osteoclast differentiation and activation in spite of impeded osteoblast-lineage differentiation under acidosis: Effects of acidosis on bone metabolism [J].

Kato, Kohtaro ;

Morita, Ikuo .

BIOSCIENCE TRENDS, 2013, 7 (01) :33-41

[3] Increased bone density in mice lacking the proton receptor OGR1 [J].

Krieger, Nancy S. ;

Yao, Zhenqiang ;

Kyker-Snowman, Kelly ;

Kim, Min Ho ;

Boyce, Brendan F. ;

Bushinsky, David A. .

KIDNEY INTERNATIONAL, 2016, 89 (03) :565-573

[4] Mechanism of acid-induced bone resorption [J].

Krieger, NS ;

Frick, KK ;

Bushinsky, DA .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2004, 13 (04) :423-436

[5] Abnormalities in Osteoclastogenesis and Decreased Tumorigenesis in Mice Deficient for Ovarian Cancer G Protein-Coupled Receptor 1 (vol 4, e5705, 2009) [J].

Li, Hui ;

Wang, Dongmei ;

Singh, Lisam Shanjukumar ;

Berk, Michael ;

Tan, Haiyan ;

Zhao, Zhenwen ;

Steinmetz, Rosemary ;

Kirmani, Kashif ;

Wei, Gang ;

Xu, Yan .

PLOS ONE, 2015, 10 (04)

[6] Proton-sensing G-protein-coupled receptors [J].

Ludwig, MG ;

Vanek, M ;

Guerini, D ;

Gasser, JA ;

Jones, CE ;

Junker, U ;

Hofstetter, H ;

Wolf, RM ;

Seuwen, K .

NATURE, 2003, 425 (6953) :93-98

[7] Regulation of inflammation by extracellular acidification and proton-sensing GPCRs [J].

Okajima, Fumikazu .

CELLULAR SIGNALLING, 2013, 25 (11) :2263-2271

[8] Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment [J].

Okito, Asuka ;

Nakahama, Ken-ichi ;

Akiyama, Masako ;

Ono, Takashi ;

Morita, Ikuo .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (02) :435-440

[9] Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line [J].

Tomura, Hideaki ;

Wang, Ju-Qiang ;

Liu, Jin-Peng ;

Komachi, Mayumi ;

Damirin, Alatangaole ;

Mogi, Chihiro ;

Tobo, Masayuki ;

Nochi, Hiromi ;

Tamoto, Koichi ;

Im, Doon-Soon ;

Sato, Koichi ;

Okajima, Fumikazu .

JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (07) :1129-1139

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