MiR-506-3p suppresses papillary thyroid cancer cells tumorigenesis by targeting YAP1

Thyroid cancer (TC) is the most common endocrine cancer in the world and about 80-85 % patients with TC belong to papillary thyroid cancer (PTC). MicroRNAs(MiRNAs) are a class of non-coding RNAs that can negatively modulate gene expression post-transcriptionally and play a role in tumorigenesis and development. The purpose of this study was to explore the biological function of miR-506-3p in PTC. We found that miR-506-3p suppressed cell proliferation disrupted the cell cycle of PTC cells in vitro. Mechanistically, we found that YAP1 was a direct target gene of miR-506-3p. Western Blot and RT-qPCR results indicated that miR-506-3p could down-regulate the expression of YAP1 at both mRNA and protein levels. Furthermore, miR-506-3p could also suppress the expression of CDK2/Cyclin E1 compound which could be affected by YAP1 gene. Therefore miR-506-3p might have proliferation-suppressive function in PTC by inhibiting YAP1 expression and regulating YAP1-CDK2/Cy clin E1 cell cycle pathway.