Investigation of injection molding of orthogonal fluidic connector for microfluidic devices

被引:4
作者
Xu, Zheng [1 ]
Cao, Dong [1 ]
Zhao, Wei [1 ]
Song, Man-cang [1 ]
Liu, Jun-shan [1 ]
机构
[1] Dalian Univ Technol, Key Lab Micro Nano Technol & Syst Liaoning Prov, Dalian 116085, Peoples R China
来源
AIP ADVANCES | 2017年 / 7卷 / 02期
基金
中国国家自然科学基金;
关键词
FABRICATION;
D O I
10.1063/1.4976618
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Orthogonal fluidic connections are essential for developing multilayered microfluidic devices. At present, most orthogonal connectors are realized by a horizontal channel and a vertical channel in different plates. Therefore, some extra alignment and adhesion processes for precise plate assembly are required. In this paper, the method of injection molding is proposed to make a one-body-type orthogonal connector in a single plastic plate. The connector was composed of a cantilevered tube and the other in the substrate. An injection mold was developed in which a side core-pulling mechanism and an ejection mechanism of push-pipes were combined to form the mold for an orthogonal connector. Both the type and the location of gate were optimized for the mold. The results showed that the fan gate in the middle position of the platewas the most suitable in term of both defect control and practicability. The effect of melt temperature was numerically investigated and then verified experimentally. With the optimized parameters, the relative length and the relative wall thickness of a cantilevered tube in the plastic part can reach 98.89% and 99.80%, respectively. Furthermore, using the plastic part as a cover plate, a three-layer plastic microfluidic device was conveniently fabricated for electrochemical detection. (C) 2017Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license.
引用
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页数:8
相关论文
共 13 条
  • [1] Attia U. M., 2013, J ENG MANUFACTURE, V228, P941
  • [2] Phase-changing sacrificial layer fabrication of multilayer polymer microfluidic devices
    Fuentes, Heman V.
    Woolley, Adam T.
    [J]. ANALYTICAL CHEMISTRY, 2008, 80 (01) : 333 - 339
  • [3] Wax-bonding 3D microfluidic chips
    Gong, Xiuqing
    Yi, Xin
    Xiao, Kang
    Li, Shunbo
    Kodzius, Rimantas
    Qin, Jianhua
    Wen, Weijia
    [J]. LAB ON A CHIP, 2010, 10 (19) : 2622 - 2627
  • [4] Patterned hydrogel microfibers prepared using multilayered microfluidic devices for guiding network formation of neural cells
    Kitagawa, Yoichi
    Naganuma, Yoji
    Yajima, Yuya
    Yamada, Masumi
    Seki, Minoru
    [J]. BIOFABRICATION, 2014, 6 (03)
  • [5] Configurable 3D-Printed millifluidic and microfluidic 'lab on a chip' reactionware devices
    Kitson, Philip J.
    Rosnes, Mali H.
    Sans, Victor
    Dragone, Vincenza
    Cronin, Leroy
    [J]. LAB ON A CHIP, 2012, 12 (18) : 3267 - 3271
  • [6] Various On-Chip Sensors with Microfluidics for Biological Applications
    Lee, Hun
    Xu, Linfeng
    Koh, Domin
    Nyayapathi, Nikhila
    Oh, Kwang W.
    [J]. SENSORS, 2014, 14 (09): : 17008 - 17036
  • [7] Fabrication of PMMA nanofluidic electrochemical chips with integrated microelectrodes
    Liu, Junshan
    Wang, Liang
    Wei Ouyang
    Wang, Wei
    Qin, Jun
    Xu, Zheng
    Xu, Shenbo
    Ge, Dan
    Wang, Longchang
    Liu, Chong
    Wang, Liding
    [J]. BIOSENSORS & BIOELECTRONICS, 2015, 72 : 288 - 293
  • [8] Microfluidic Systems for Biosensing
    Liu, Kuo-Kang
    Wu, Ren-Guei
    Chuang, Yun-Ju
    Khoo, Hwa Seng
    Huang, Shih-Hao
    Tseng, Fan-Gang
    [J]. SENSORS, 2010, 10 (07) : 6623 - 6661
  • [9] Perforated membrane method for fabricating three-dimensional polydimethylsiloxane microfluidic devices
    Luo, Yiqi
    Zare, Richard N.
    [J]. LAB ON A CHIP, 2008, 8 (10) : 1688 - 1694
  • [10] Microfluidic diagnostics for the developing world
    Mao, Xiaole
    Huang, Tony Jun
    [J]. LAB ON A CHIP, 2012, 12 (08) : 1412 - 1416