Direct and Indirect Effects of Crisaborole Ointment on Quality of Life in Patients with Atopic Dermatitis: A Mediation Analysis

被引：7

作者：

Simpson, Eric L. ^{[1
]}

Yosipovitch, Gil ^{[2
]}

Bushmakin, Andrew G. ^{[3
]}

Cappelleri, Joseph C. ^{[3
]}

Luger, Thomas ^{[4
]}

Staender, Sonja ^{[5
]}

Tom, Wynnis L. ^{[6
,7
]}

Ports, William C. ^{[3
]}

Zielinski, Michael A. ^{[8
]}

Tallman, Anna M. ^{[9
]}

Tans, Huaming ^{[3
]}

Gerber, Robert A. ^{[3
]}

机构：

[1] Oregon Hlth & Sci Univ, 3303 SW Bond Ave, Portland, OR 97225 USA

[2] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[3] Pfizer Inc, Groton, CT 06340 USA

[4] Univ Hosp Munster, Munster, Germany

[5] Univ Hosp Munster, Ctr Chron Pruritus, Munster, Germany

[6] Univ Calif San Diego, San Diego, CA 92103 USA

[7] Rady Childrens Hosp San Diego, San Diego, CA USA

[8] Pfizer Inc, Collegeville, PA USA

[9] Pfizer Inc, New York, NY USA

来源：

ACTA DERMATO-VENEREOLOGICA | 2019年 / 99卷 / 09期

关键词：

crisaborole; atopic dermatitis; quality of life; mediation; pruritus; CHRONIC PRURITUS; INDEX CDLQI; ITCH; SEVERITY; ECZEMA; MANAGEMENT; CHILDREN; DISEASE; HEALTH;

D O I：

10.2340/00015555-3181

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Crisaborole ointment is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis. Using pooled data from two phase 3 studies (NCT02118766/NCT02118792), mediation modeling determined the interrelationship among pruritus, quality of life (QoL), and treatment. Patients aged >= 2 years received crisaborole ointment, 2%, or vehicle twice daily for 28 days. QoL measures were Dermatology Life Quality Index (DLQI) (>= 16 years) and Children's Dermatology Life Quality Index (CDLQI) (2-15 years). Pruritus was assessed by the Severity of Pruritus Scale (4-point scale from 0 to 3). The indirect effect of crisaborole on QoL mediated through its effect on pruritus was 51% (DLQI model, p < 0.05) and 72% (CDLQI model, p < 0.05). Direct effect (other effects) on QoL was 49% (DLQI model, p < 0.05) and 28% (CDLQI model, p > 0.05). Mediation modeling shows that crisaborole affects QoL mostly indirectly through pruritus severity reduction.

引用

页码：756 / 761

页数：6

共 41 条

[1] [Anonymous], 2017, EUCR CRIS OINTM 2 TO
[2] [Anonymous], 2015, EXPLANATION CAUSAL I
[3] THE MODERATOR MEDIATOR VARIABLE DISTINCTION IN SOCIAL PSYCHOLOGICAL-RESEARCH - CONCEPTUAL, STRATEGIC, AND STATISTICAL CONSIDERATIONS
BARON, RM
KENNY, DA
[J]. JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1986, 51 (06) : 1173 - 1182
[4] Mechanisms of disease: Atopic dermatitis
Bieber, Thomas
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) : 1483 - 1494
[5] Blume-Peytavi U, 2012, J EUR ACAD DERMATOL
[6] Boguniewicz M, 2017, MAUI DERM 2017 JUN 1
[7] The relationship between pruritus and the clinical signs of psoriasis in patients receiving tofacitinib
Bushmakin, Andrew G.
Mamolo, Carla
Cappelleri, Joseph C.
Stewart, Michelle
[J]. JOURNAL OF DERMATOLOGICAL TREATMENT, 2015, 26 (01) : 19 - 22
[8] Cappelleri JC, 2014, CH CRC BIOSTAT SER, P221
[9] Itch characteristics in atopic dermatitis: results of a web-based questionnaire
Dawn, A.
Papoiu, A. D. P.
Chan, Y. H.
Rapp, S. R.
Rassette, N.
Yosipovitch, G.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (03) : 642 - 644
[10] The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association
Drucker, Aaron M.
Wang, Annie R.
Li, Wen-Qing
Sevetson, Erika
Block, Julie K.
Qureshi, Abrar A.
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (01) : 26 - 30

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