Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis

被引：3
作者：
Song, Lingxie [1 ,2 ]
Meng, Lian [1 ,2 ]
Peng, Jifeng [1 ,2 ]
Wang, Ping [1 ,2 ]
Qi, Shengnan [1 ,2 ]
Li, Wanyu [1 ,2 ]
Liu, Chunxia [1 ,2 ,3 ]
Li, Feng [1 ,2 ,3 ]
机构：
[1] Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Xinjiang, Peoples R China
[2] Chinese Minist Educ, Key Labs Xinjiang Endem & Ethn Dis, Shihezi 832002, Xinjiang, Peoples R China
[3] Shihezi Univ, Sch Med, Dept Pathol, Affiliated Hosp 1, Xinjiang 832002, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
cervical cancer; clinicopathological parameters; expression; meta-analysis; Notch1; HUMAN-PAPILLOMAVIRUS; BREAST-CANCER; KAPPA-B; GROWTH; PROGNOSIS; INVASION; TARGET; CELLS;
D O I：
10.2217/bmm.15.103
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer. Methods: Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis. Results: A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer. Conclusion: Notch1 over-expression indicated aggressive biological behaviors.
引用
收藏
页码：63 / 72
页数：10
相关论文
共 42 条
[1]   Non-canonical Notch signaling: emerging role and mechanism [J].
Andersen, Peter ;
Uosaki, Hideki ;
Shenje, Lincoln T. ;
Kwon, Chulan .
TRENDS IN CELL BIOLOGY, 2012, 22 (05) :257-265
[2]  
[Anonymous], CHINESE MED EQUIPMEN
[3]  
[Anonymous], CHINESE J CLIN ONCOL
[4]  
[Anonymous], J PATHOL
[5]  
[Anonymous], CHINESE J OBSTET GYN
[6]  
[Anonymous], SHANDONG MED
[7]  
[Anonymous], CHINESE FOREIGN MED
[8]   Notch signaling in pancreatic cancer: oncogene or tumor suppressor? [J].
Avila, Jacqueline L. ;
Kissil, Joseph L. .
TRENDS IN MOLECULAR MEDICINE, 2013, 19 (05) :320-327
[9]   Non-canonical Notch signaling in cancer and immunity [J].
Ayaz, Furkan ;
Osborne, Barbara A. .
FRONTIERS IN ONCOLOGY, 2014, 4
[10]   Notch activation stimulates migration of breast cancer cells and promotes tumor growth [J].
Bolos, Victoria ;
Mira, Emilia ;
Martinez-Poveda, Beatriz ;
Luxan, Guillermo ;
Canamero, Marta ;
Martinez-A, Carlos ;
Manes, Santos ;
Luis de la Pompa, Jose .
BREAST CANCER RESEARCH, 2013, 15 (04)
12345