Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

被引：8

作者：

D'Errico, Stefano ^{[1
]}

Oliviero, Giorgia ^{[1
]}

Borbone, Nicola ^{[1
]}

Di Gennaro, Elena ^{[2
]}

Zotti, Andrea Ilaria ^{[2
]}

Budillon, Alfredo ^{[2
]}

Cerullo, Vincenzo ^{[3
]}

Nici, Fabrizia ^{[1
]}

Mayol, Luciano ^{[1
]}

Piccialli, Vincenzo ^{[4
]}

Piccialli, Gennaro ^{[1
,5
]}

机构：

[1] Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy

[2] Fdn G Pascale IRCCS, Ist Nazl Tumori, Expt Pharmacol, I-80131 Naples, Italy

[3] Univ Helsinki, Fac Pharm, Div Biopharmaceut & Pharmacokinet, Helsinki 00790, Finland

[4] Univ Naples Federico II, Dipartimento Sci Chim, I-80126 Naples, Italy

[5] Natl Res Council Italy, Inst Prot Biochem, I-80131 Naples, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 34期

关键词：

Platinum; Nucleosides; Antitumor agents; Medicinal chemistry; PHARMACOLOGICAL EVALUATION; ANTICANCER DRUG; PLATINUM; NUCLEOSIDE; CISPLATIN; CANCER; TUBERCIDIN; SUPPRESSION; RESISTANCE; EFFICACY;

D O I：

10.1002/ejoc.201500998

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its anti-proliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.

引用

页码：7550 / 7556

页数：7

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[21] Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis [J].