Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice

被引：24
作者：
Grootendorst, J [1 ]
Kempes, MM [1 ]
Lucassen, PJ [1 ]
Dalm, S [1 ]
de Kloet, ER [1 ]
Oitzl, MS [1 ]
机构：
[1] Leiden Univ, Med Ctr, Leiden Amsterdam Ctr Drug Res, Div Med Pharmacol, NL-2300 RA Leiden, Netherlands
来源：
BRAIN RESEARCH | 2002年 / 953卷 / 1-2期
关键词：
Alzheimer's disease; hippocampus; spatial learning; glucocorticoid; hypothalamic-pituitary-adrenal axis; apolipoprotein E;
D O I：
10.1016/S0006-8993(02)03399-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previously, we found that repeated exposure to predator stress corrected the deficit in spatial learning of apolipoprotein E-knockout (apoE0/0) mice, but impaired cognitive performance of wild-type mice. Here we show that elevated corticosterone concentrations, accomplished by subcutaneously implanted pellets, results in similar genotype-related effects on water maze learning: while apoE0/0 mice improved their spatial learning abilities, wild-type mice (C57/B16J) became impaired. These results suggest that corticosterone mediates the lasting effects of environmental challenges on apoE-genotype related cognitive performance. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：281 / 285
页数：5
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