Effects of Vitamin D3 in Long-Term Ovariectomized Rats Subjected to Chronic Unpredictable Mild Stress: BDNF, NT-3, and NT-4 Implications

被引:43
作者
Koshkina, Alexandra [1 ]
Dudnichenko, Tatyana [2 ]
Baranenko, Denis [1 ]
Fedotova, Julia [1 ,3 ]
Drago, Filippo [4 ]
机构
[1] ITMO Univ, Fac Food & Bioengn, 49 Kronverksky Pr, St Petersburg 197101, Russia
[2] North Western State Med Univ, Dept Obstet & Gynecol, 41 Kirochnaya Str, St Petersburg 191015, Russia
[3] Russian Acad Sci, Lab Neuroendocrinol, IP Pavlov Inst Physiol, 6 Emb Makarova, St Petersburg 199034, Russia
[4] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Biol Tower,Via S Sofia 97, I-95123 Catania, Italy
基金
俄罗斯科学基金会;
关键词
vitamin D-3; long-term ovariectomy; chronic unpredictable mild stress; BDNF; NT-3; NT-4; SERUM 25-HYDROXYVITAMIN D; FORCED SWIMMING TEST; NEUROTROPHIC FACTOR; BRAIN-DEVELOPMENT; ANIMAL-MODELS; DEPRESSION; WOMEN; ANTIDEPRESSANTS; ANXIETY; MICE;
D O I
10.3390/nu11081726
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The purpose of this study was to explore the antidepressant-like effects of vitamin D-3 at different doses (1.0, 2.5, and 5.0 mg/kg sc) on a model of depression produced by chronic unpredictable mild stress (CUMS) for 28 days in long-term (3 months) ovariectomized (OVX) adult rats. Sucrose preference (SPT), forced swimming (FST) and open-field (OFT) tests were conducted to examine the depression-like state. Serum corticosterone/adrenocorticotrophic hormone (ACTH) levels and hippocampal brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-3/NT-4 expressions by ELISA kits and/or western blotting were determined to assess the possible mechanisms of the vitamin D-3 effects on the depression-like profile in long-term OVX rats subjected to CUMS. The results showed that vitamin D-3 (5.0 mg/kg), as well as fluoxetine treatment, considerably reversed the depression-like state in the SPT and FST, decreased serum corticosterone/ACTH levels, and increased BDNF and NT-3/NT-4 levels in the hippocampus of long-term OVX rats compared to OVX rats with CUMS (p < 0.05). Thus, a high dose of vitamin D-3 (5.0 mg/kg sc) could improve the depression-like profile in long-term OVX adult female rats subjected to the CUMS procedure, which might be mediated by the regulation of BDNF and the NT-3/NT-4 signaling pathways in the hippocampus, as well as the corticosterone/ACTH levels of the blood serum.
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页数:22
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