18F-FDG PET/CT in the detection of asymptomatic malignant melanoma recurrence

被引:9
作者
Lawal, Ismaheel
Lengana, Thabo
Ololade, Kehinde
Boshomane, Tebatso
Reyneke, Florette
Modiselle, Moshe
Vorster, Mariza
Sathekge, Mike [1 ,2 ]
机构
[1] Univ Pretoria, Dept Nucl Med, Private Bag X169, ZA-0001 Pretoria, South Africa
[2] Steve Biko Acad Hosp, Private Bag X169, ZA-0001 Pretoria, South Africa
来源
NUKLEARMEDIZIN-NUCLEAR MEDICINE | 2017年 / 56卷 / 03期
关键词
F-18-FDG PET/CT; malignant melanoma; recurrence; asymptomatic; FOLLOW-UP; EPIDEMIOLOGY; INDICATORS; CANCER; SCAN;
D O I
10.3413/Nukmed-0864-16-11
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Aim: To evaluate the diagnostic accuracy of FDG PET/CT in the detection of asymptomatic recurrence in patients with malignant melanoma who have had resection of their primary lesion. We also aimed to determine the pattern and factors predisposing to disease recurrence. Methods: Patients with malignant melanoma who have had surgical resection of their disease and without any clinical evidence of disease recurrence were followed up with FDG PET/CT. The diagnostic accuracy of FDG PET/CT, pattern of recurrence and factors predictive of disease recurrence were determined. Results: A total of 144 patients were followed-up for a median period of 50.50 months. Asymptomatic recurrence was seen in 37 patients (25.7%) with a median time to recurrence of 20 months. Lymph node was the commonest site of asymptomatic recurrence. Sex, tumour depth, histology type and presence of nodal metastasis were significant predictors of tumour recurrence. Age, race, site of primary lesion, type of lymph node resection were not significant predictors of disease recurrence. Race has a significant effect on the histological subtype of tumour (nodular maligna was more common in Caucasian while acral lentiginous was more prevalent in the Blacks) and the site of the primary lesion (lower limb in Blacks and trunk in Caucasians). Sensitivity, specificity and accuracy of FDG PET/CT for the detection of disease recurrence were 94.5 %, 87.6% and 89.6 % respectively. Conclusion: FDG PET/CT is a suitable modality for early detection of asymptomatic recurrence of malignant melanoma. Asymptomatic recurrence most commonly occurs in lymph nodes. Sex, nodal metastasis and tumour pathologic features are predictors of recurrence.
引用
收藏
页码:83 / 89
页数:7
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