Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

被引：37
作者：
Liu, Xin-Ming [1 ]
Miller, Scott C. [2 ]
Wang, Dong [1 ]
机构：
[1] Univ Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA
[2] Univ Utah, Dept Radiol, Div Radiobiol, Salt Lake City, UT 84112 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 02期
关键词：
HPMA copolymers; Musculoskeletal diseases; Infectious diseases; Arthritis; Bone-targeting; Central nervous system (CNS); DRUG-DELIVERY SYSTEM; OVARIAN-CARCINOMA CELLS; CENTRAL-NERVOUS-SYSTEM; SPINAL-CORD REPAIR; HEPATITIS-B-VIRUS; RHEUMATOID-ARTHRITIS; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS; CATHEPSIN-K; VISCERAL LEISHMANIASIS; ANTISENSE OLIGONUCLEOTIDES;
D O I：
10.1016/j.addr.2009.10.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：258 / 271
页数：14
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[1]   Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases [J].
Sadraeian, Mohammad ;
Maleki, Reza ;
Moraghebi, Mahta ;
Bahrami, Abasalt .
MOLECULES, 2024, 29 (13)
[2]   Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases [J].
Katoh, Masaru .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2014, 2
[3]   Potential of epigenetic therapies in non-cancerous conditions [J].
Mau, Theresa ;
Yung, Raymond .
FRONTIERS IN GENETICS, 2014, 5
[4]   Cellular and subcellular interactions of graphene-based materials with cancerous and non-cancerous cells [J].
Rahimi, Shadi ;
Chen, Yanyan ;
Zareian, Mohsen ;
Pandit, Santosh ;
Mijakovic, Ivan .
ADVANCED DRUG DELIVERY REVIEWS, 2022, 189
[5]   Ornithine decarboxylase activity in the non-cancerous hepatic tissue of patients with hepatocellular carcinoma [J].
Kubo, S ;
Tamori, A ;
Omura, T ;
Ikebe, T ;
Wakasa, K ;
Hirohashi, K ;
Kinoshita, H ;
Otani, S .
HEPATO-GASTROENTEROLOGY, 2000, 47 (33) :820-823
[6]   Exploiting passive nanomedicine accumulation at sites of enhanced vascular permeability for non-cancerous applications [J].
Durymanov, Mikhail ;
Kamaletdinova, Tatiana ;
Lehmann, Sarah E. ;
Reineke, Joshua .
JOURNAL OF CONTROLLED RELEASE, 2017, 261 :10-22
[7]   Risk of Developing Non-Cancerous Central Nervous System Diseases Due to Ionizing Radiation Exposure during Adulthood: Systematic Review and Meta-Analyses [J].
Lopes, Julie ;
Leuraud, Klervi ;
Klokov, Dmitry ;
Durand, Christelle ;
Bernier, Marie-Odile ;
Baudin, Clemence .
BRAIN SCIENCES, 2022, 12 (08)
[8]   Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues [J].
Jin, Yan ;
Gao, Hengjun ;
Chen, Hao ;
Wang, Jian ;
Chen, Min ;
Li, Guohua ;
Wang, Liwei ;
Gu, Jianren ;
Tu, Hong .
CANCER LETTERS, 2013, 335 (02) :447-454
[9]   MiR-451 in Inflammatory Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Applications-A Comprehensive Review Beyond Oncology [J].
Wang, Fei-Xiang ;
Mu, Guo ;
Yu, Zi-Hang ;
Qin, Zhen-Shan ;
Zhao, Xing ;
Shi, Zu-An ;
Fan, Xin ;
Liu, Li ;
Chen, Ye ;
Zhou, Jun .
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2025, 47 (02)
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