Severe Coronavirus Disease 2019 That Recovered from Respiratory Failure by Treatment That Included High-dose Intravenous Immunoglobulin

被引：4

作者：

Suzuki, Yasuhito ^{[1
]}

Tanino, Yoshinori ^{[1
]}

Nikaido, Takefumi ^{[1
]}

Minemura, Hiroyuki ^{[1
]}

Umeda, Takashi ^{[1
]}

Rikimaru, Mami ^{[1
]}

Onuma, Takumi ^{[1
]}

Naito, Shotaro ^{[2
]}

Takiguchi, Yoshinori ^{[3
]}

Tomita, Hikaru ^{[1
]}

Kawamata, Takaya ^{[1
]}

Togawa, Ryuichi ^{[1
]}

Sato, Yuki ^{[1
]}

Uematsu, Manabu ^{[1
]}

Morimoto, Julia ^{[1
]}

Kitakawa, Kadzuhiro ^{[4
]}

Tsukada, Yasuhiko ^{[5
]}

Nakamura, Kiwamu ^{[6
]}

Kanemitsu, Keiji ^{[6
]}

Iseki, Ken ^{[5
]}

Shibata, Yoko ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Pulm Med, Fukushima, Japan

[2] Fukushima Med Univ, Dept Gen Internal Med, Fukushima, Japan

[3] Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Fukushima, Japan

[4] Fukushima Prefectural Inst Publ Hlth, Fukushima, Japan

[5] Fukushima Med Univ, Dept Emergency & Crit Care Med, Fukushima, Japan

[6] Fukushima Med Univ, Dept Infect Control, Fukushima, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 03期

关键词：

coronavirus disease 2019; COVID-19; intravenous immunoglobulin; severe acute respiratory syndrome-coronavirus-2; acute respiratory distress syndrome; deterioration; COVID-19; MODULATE;

D O I：

10.2169/internalmedicine.6326-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of severe coronavirus disease 2019 (COVID-19) in which high-dose intravenous immunoglobulin (IVIg) treatment achieved significant clinical improvement of deterioration of pulmonary inflammation after temporary clinical improvement. In the present case, clinical and radiological deterioration occurred despite a decrease in viral load, suggesting that deterioration was caused by reactivation of proinflammatory factors. such as tumor necrosis factor-a and interleukin-6, rather than direct viral effects. IVIg treatment may provide not only immunosuppressive effects but also inhibition of proinflammatory cytoldnes, indicating that treatment including IVIg may be effective by inhibiting cytokine storm in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.

引用

页码：457 / 461

页数：5

共 50 条

[1] High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China
Cao, Wei
Liu, Xiaosheng
Hong, Ke
Ma, Zhiyong
Zhang, Yuelun
Lin, Ling
Han, Yang
Xiong, Yong
Liu, Zhengyin
Ruan, Lianguo
Li, Taisheng
FRONTIERS IN IMMUNOLOGY, 2021, 12
[2] High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019
Xia, Guozhi
Fan, Di
He, Yanru
Zhu, Yaohu
Zheng, Qiangsun
NUTRITION, 2021, 91-92
[3] High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China (vol 12, 627844, 2021)
Cao, Wei
Liu, Xiaosheng
Hong, Ke
Ma, Zhiyong
Zhang, Yuelun
Lin, Ling
Han, Yang
Xiong, Yong
Liu, Zhengyin
Ruan, Lianguo
Li, Taisheng
FRONTIERS IN IMMUNOLOGY, 2021, 12
[4] High-dose intravenous immunoglobulin treatment of multiple sclerosis
L. Durelli
G. Isoardo
Neurological Sciences, 2002, 23 : S39 - S48
[5] The Efficacy and Safety of High-Dose Intravenous Immunoglobulin in the Treatment of Kawasaki Disease: How Can We Predict Resistance to Intravenous Immunoglobulin Treatment of Kawasaki Disease?
Han, Ji Whan
KOREAN CIRCULATION JOURNAL, 2017, 47 (02) : 179 - 181
[6] HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN THERAPY FOR RHESUS HEMOLYTIC-DISEASE
DAGOGLU, T
OVALI, F
SAMANCI, N
BENGISU, E
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1995, 23 (04) : 264 - 271
[7] High-dose intravenous immunoglobulin in the treatment of adult patients with bullous pemphigoid
Gaitanis, Georgios
Alexis, Ioannis
Pelidou, Sygkliti-Henrietta
Gazi, Irene F.
Kyritsis, Athanasios P.
Elisaf, Moses S.
Bassukas, Ioannis D.
EUROPEAN JOURNAL OF DERMATOLOGY, 2012, 22 (03) : 363 - 369
[8] SUCCESSFUL TREATMENT OF PSYCHOSIS SECONDARY TO SLE WITH HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN
TOMER, Y
SHOENFELD, Y
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 1992, 10 (04) : 391 - 393
[9] Scleromyxoedema: treatment of cutaneous and systemic manifestations with high-dose intravenous immunoglobulin
Kulczycki, A
Nelson, M
Eisen, A
Heffernan, M
BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (06) : 1276 - 1281
[10] High-dose intravenous immunoglobulin (hdIVIg) in the treatment of autoimmune blistering disorders
Jolles, S
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 129 (03) : 385 - 389

← 1 2 3 4 5 →