Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action

被引：23

作者：

Wu, Hucong ^{[1
,2
]}

Liu, Jiaqi ^{[1
,2
]}

Yin, Yi ^{[1
,2
]}

Zhang, Dong ^{[1
]}

Xia, Pengpeng ^{[1
,2
]}

Zhu, Guoqiang ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2019年 / 2019卷

基金：

美国国家科学基金会;

关键词：

COLON CARCINOGENESIS; PROLIFERATIVE ACTIVITY; AUTOPHAGY; CELLS; APOPTOSIS; EXPRESSION; ANGIOGENESIS; TUMORS; 1,2-DIMETHYLHYDRAZINE; SENESCENCE;

D O I：

10.1155/2019/9740568

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g., circadian rhythm, immune modulation, and antioncogenic action), can be present in almost all organisms and found in various tissues including gastrointestinal tract. Notably, melatonin disruption is closely associated with the elevation of CRC incidence, indicating that melatonin is effective in suppressing CRC development and progression. Mechanistically, melatonin favors in activating apoptosis and colon cancer immunity, while reducing proliferation, autophagy, metastasis, and angiogenesis, thereby exerting its anticarcinogenic effects.)is review highlights that melatonin can be an adjuvant therapy and be beneficial in treating patients suffering from CRC.

引用

页数：6