Three-dimensionally two-photon lithography realized vascular grafts

被引：24
|
作者：
Limongi, T. [1 ]
Brigo, L. [2 ]
Tirinato, L. [3 ]
Pagliari, F. [3 ]
Gandin, A. [2 ,4 ,5 ]
Contessotto, P. [2 ]
Giugni, A. [6 ]
Brusatin, G. [2 ,4 ,5 ]
机构：
[1] Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy
[2] Univ Padua, Dept Ind Engn, Via Marzolo 9, I-35131 Padua, Italy
[3] German Canc Res Ctr, Div BioMed Phys Radiat Oncol, D-69120 Heidelberg, Germany
[4] Univ Padua, Dept Mol Med, Via Ugo Bassi 58-B, I-35131 Padua, Italy
[5] INSTM, Dept Mol Med, Via Ugo Bassi 58-B, I-35131 Padua, Italy
[6] King Abdullah Univ Sci & Technol KAUST, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia
来源：
BIOMEDICAL MATERIALS | 2021年 / 16卷 / 03期
关键词：
microstructured scaffolds; 3D fabrication; two-photon laser lithography; endothelial cells; vascular tissue engineering;
D O I：
10.1088/1748-605X/abca4b
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.
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收藏
页数：9
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