Three-dimensionally two-photon lithography realized vascular grafts

被引：24

作者：

Limongi, T. ^{[1
]}

Brigo, L. ^{[2
]}

Tirinato, L. ^{[3
]}

Pagliari, F. ^{[3
]}

Gandin, A. ^{[2
,4
,5
]}

Contessotto, P. ^{[2
]}

Giugni, A. ^{[6
]}

Brusatin, G. ^{[2
,4
,5
]}

机构：

[1] Politecn Torino, Dept Appl Sci & Technol, I-10129 Turin, Italy

[2] Univ Padua, Dept Ind Engn, Via Marzolo 9, I-35131 Padua, Italy

[3] German Canc Res Ctr, Div BioMed Phys Radiat Oncol, D-69120 Heidelberg, Germany

[4] Univ Padua, Dept Mol Med, Via Ugo Bassi 58-B, I-35131 Padua, Italy

[5] INSTM, Dept Mol Med, Via Ugo Bassi 58-B, I-35131 Padua, Italy

[6] King Abdullah Univ Sci & Technol KAUST, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia

来源：

BIOMEDICAL MATERIALS | 2021年 / 16卷 / 03期

关键词：

microstructured scaffolds; 3D fabrication; two-photon laser lithography; endothelial cells; vascular tissue engineering;

D O I：

10.1088/1748-605X/abca4b

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.

引用

页数：9

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