Monoclonal antibody specific for IDH1 R132H mutation

被引：339

作者：

Capper, David ^{[1
]}

Zentgraf, Hanswalter ^{[2
]}

Balss, Joerg ^{[3
]}

Hartmann, Christian ^{[1
,3
]}

von Deimling, Andreas ^{[1
,3
]}

机构：

[1] Heidelberg Univ, Dept Neuropathol, Inst Pathol, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Monoclonal Antibody Unit, D-69120 Heidelberg, Germany

[3] German Canc Res Ctr, Clin Cooperat Unit Neuropathol G380, D-69120 Heidelberg, Germany

来源：

ACTA NEUROPATHOLOGICA | 2009年 / 118卷 / 05期

关键词：

IDH1; Monoclonal antibody; Immunohistochemistry; Astrocytoma; Oligodendroglioma; Oligoastrocytoma; CODON; 132; MUTATION; GLIOMAS;

D O I：

10.1007/s00401-009-0595-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. We developed a mouse monoclonal antibody targeting the IDH1 R132H mutation. Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens. This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein.

引用

页码：599 / 601

页数：3

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