Postmortem CT lung findings in decedents with Covid-19: A review of 14 decedents and potential triage implications

被引:14
作者
Helmrich, Emily [1 ]
Decker, Lauren [1 ]
Adolphi, Natalie [2 ]
Makino, Yohsuke [3 ]
机构
[1] Univ New Mexico, MSC07 4040,1 Univ New Mexico, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Dept Biochem & Mol Biol, MSC08-4670,1 Univ New Mexico, Albuquerque, NM 87101 USA
[3] Univ Tokyo, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan
来源
FORENSIC IMAGING | 2020年 / 23卷
关键词
Coronavirus; COVID-19; PMCT; Postmortem CT; Autopsy; Pulmonary pathology; CORONAVIRUS DISEASE 2019; CHEST CT; CLINICAL CHARACTERISTICS; AUTOPSY;
D O I
10.1016/j.fri.2020.200419
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: Computed tomography has significant utility as a diagnostic tool for coronavirus disease 2019 (COVID19) in the clinical setting. COVID-19 deaths are sometimes examined by forensic pathologists, often in the setting of an unknown diagnosis. We assessed the utility of postmortem computed tomography (PMCT) for use as a triage tool for these autopsy examinations. Materials and methods: We reviewed PMCT findings in 14 and histopathology in 11 decedents who were positive for COVID-19. Results: The predominant imaging findings were bilateral mixed densities, in either a diffuse or peripheral distribution, with traction bronchiectasis, and/or crazy paving. In particular, traction bronchiectasis, ill-defined rounded consolidations, and reverse halo sign are useful when distinguishing from other postmortem changes. Conclusion: We conclude that triage with a PMCT may aid the forensic pathologist in diagnosing possible COVID19 infection prior to autopsy examination.
引用
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页数:6
相关论文
共 22 条
[1]   Inside the lungs of COVID-19 disease [J].
Aguiar, Diego ;
Lobrinus, Johannes Alexander ;
Schibler, Manuel ;
Fracasso, Tony ;
Lardi, Christelle .
INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2020, 134 (04) :1271-1274
[2]   Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases [J].
Ai, Tao ;
Yang, Zhenlu ;
Hou, Hongyan ;
Zhan, Chenao ;
Chen, Chong ;
Lv, Wenzhi ;
Tao, Qian ;
Sun, Ziyong ;
Xia, Liming .
RADIOLOGY, 2020, 296 (02) :E32-E40
[3]   Performance of Radiologists in Differentiating COVID-19 from Non-COVID-19 Viral Pneumonia at Chest CT [J].
Bai, Harrison X. ;
Hsieh, Ben ;
Xiong, Zeng ;
Halsey, Kasey ;
Choi, Ji Whae ;
Tran, Thi My Linh ;
Pan, Ian ;
Shi, Lin-Bo ;
Wang, Dong-Cui ;
Mei, Ji ;
Jiang, Xiao-Long ;
Zeng, Qiu-Hua ;
Egglin, Thomas K. ;
Hu, Ping-Feng ;
Agarwal, Saurabh ;
Xie, Fang-Fang ;
Li, Sha ;
Healey, Terrance ;
Atalay, Michael K. ;
Liao, Wei-Hua .
RADIOLOGY, 2020, 296 (02) :E46-E54
[4]  
Barton LM, 2020, AM J CLIN PATHOL, V153, P725, DOI [10.1093/AJCP/AQAA062, 10.1093/ajcp/aqaa062]
[5]   Chest CT Findings in Coronavirus Disease 2019 (COVID-19): Relationship to Duration of Infection [J].
Bernheim, Adam ;
Mei, Xueyan ;
Huang, Mingqian ;
Yang, Yang ;
Fayad, Zahi A. ;
Zhang, Ning ;
Diao, Kaiyue ;
Lin, Bin ;
Zhu, Xiqi ;
Li, Kunwei ;
Li, Shaolin ;
Shan, Hong ;
Jacobi, Adam ;
Chung, Michael .
RADIOLOGY, 2020, 295 (03) :685-691
[6]   The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities [J].
Buja, Louis Maximilian ;
Wolf, Dwayne A. ;
Zhao, Bihong ;
Akkanti, Bindu ;
McDonald, Michelle ;
Lelenwa, Laura ;
Reilly, Noah ;
Ottaviani, Giulia ;
Elghetany, M. Tarek ;
Trujillo, Daniel Ocazionez ;
Aisenberg, Gabriel M. ;
Madjid, Mohammad ;
Kar, Biswajit .
CARDIOVASCULAR PATHOLOGY, 2020, 48
[7]   A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].
Chan, Jasper Fuk-Woo ;
Yuan, Shuofeng ;
Kok, Kin-Hang ;
To, Kelvin Kai-Wang ;
Chu, Hin ;
Yang, Jin ;
Xing, Fanfan ;
Liu, Jieling ;
Yip, Cyril Chik-Yan ;
Poon, Rosana Wing-Shan ;
Tsoi, Hoi-Wah ;
Lo, Simon Kam-Fai ;
Chan, Kwok-Hung ;
Poon, Vincent Kwok-Man ;
Chan, Wan-Mui ;
Ip, Jonathan Daniel ;
Cai, Jian-Piao ;
Cheng, Vincent Chi-Chung ;
Chen, Honglin ;
Hui, Christopher Kim-Ming ;
Yuen, Kwok-Yung .
LANCET, 2020, 395 (10223) :514-523
[8]   Role of PMCT as a triage tool between external inspection and full autopsy - Case series and review [J].
Chatzaraki, Vasiliki ;
Heimer, Jakob ;
Thali, Michael ;
Dally, Annika ;
Schweitzer, Wolf .
JOURNAL OF FORENSIC RADIOLOGY AND IMAGING, 2018, 15 :26-38
[9]  
Chung MS, 2020, EUR RADIOL, V30, P2182, DOI [10.1007/s00330-019-06574-1, 10.1148/radiol.2020200230]
[10]   Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR [J].
Fang, Yicheng ;
Zhang, Huangqi ;
Xie, Jicheng ;
Lin, Minjie ;
Ying, Lingjun ;
Pang, Peipei ;
Ji, Wenbin .
RADIOLOGY, 2020, 296 (02) :E115-E117