Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species

被引：138

作者：

Sun, XG ^{[1
]}

Majumder, P ^{[1
]}

Shioya, H ^{[1
]}

Wu, F ^{[1
]}

Kumar, S ^{[1
]}

Weichselbaum, R ^{[1
]}

Kharbanda, S ^{[1
]}

Kufe, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2000年 / 275卷 / 23期

关键词：

D O I：

10.1074/jbc.C000099200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ubiquitously expressed c-Abl protein tyrosine kinase localizes to both the nucleus and cytoplasm. The nuclear form of c-Abl is activated in the cellular response to genotoxic stress. Here we show that cytoplasmic c-Abl is activated by oxidative stress, The results also demonstrate that mitochondrial cytochrome c is released in the cellular response to H2O2 and that this effect is mediated by a c-Abl-dependent mechanism. In concert with these results, we show that H2O2-induced apoptosis is attenuated in c-Abl-deficient cells. These findings demonstrate that cytoplasmic c-Abl is involved in the apoptotic response of cells to oxidative stress.

引用

页码：17237 / 17240

页数：4