Abdominal obesity and metabolic syndrome

被引:3293
作者
Despres, Jean-Pierre
Lemieux, Isabelle
机构
[1] Hop Laval, Res Ctr, Quebec Heart Inst, Ste Foy, PQ G1V 4G5, Canada
[2] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Quebec City, PQ G1K 7P4, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1038/nature05488
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal obesity - the most prevalent manifestation of metabolic syndrome - is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis. Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale.
引用
收藏
页码:881 / 887
页数:7
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