Beyond TGF-β: a prostaglandin promotes fibrosis

被引：32

作者：

Olman, Mitchell A. ^{[1
,2
]}

机构：

[1] Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Resp Inst, Cleveland, OH 44195 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 12期

关键词：

INDUCED PULMONARY FIBROSIS; MYOFIBROBLAST; FIBROBLASTS; ACTIVATION; RECEPTOR; CATENIN;

D O I：

10.1038/nm1209-1360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-beta (TGF-beta). Prostaglandin F(2 alpha) and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-beta (pages 1426-1430).

引用

页码：1360 / 1361

页数：2

共 15 条

[1] Commercially Available Prostaglandin Analogs for the Reduction of Intraocular Pressure: Similarities and Differences
Bean, Gerald W.
Camras, Carl B.
[J]. SURVEY OF OPHTHALMOLOGY, 2008, 53 : S69 - S84
[2] Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner
Ding, Qiang
Gladson, Candece L.
Wu, Hongju
Hayasaka, Haurko
Olman, Mitchell A.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (40) : 26839 - 26849
[3] Cellular conditioning and activation of β-catenin signaling by the FPB prostanoid receptor
Fujino, H
Srinivasan, D
Regan, JW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) : 48786 - 48795
[4] The myofibroblast - One function, multiple origins
Hinz, Boris
Phan, Sem H.
Thannickal, Victor J.
Galli, Andrea
Bochaton-Piallat, Marie-Luce
Gabbiani, Giulio
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (06) : 1807 - 1816
[5] Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia
Huang, Steven K.
Wettlaufer, Scott H.
Hogaboam, Cory M.
Flaherty, Kevin R.
Martinez, Fernando J.
Myers, Jeffrey L.
Colby, Thomas V.
Travis, William D.
Toews, Galen B.
Peters-Golden, Marc
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (01) : 66 - 74
[6] Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-β in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
Keerthisingam, CB
Jenkins, RG
Harrison, NK
Hernandez-Rodriguez, NA
Booth, H
Laurent, GJ
Hart, SL
Foster, ML
McAnulty, RJ
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (04) : 1411 - 1422
[7] Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Kim, Kevin K.
Wei, Ying
Szekeres, Charles
Kugler, Matthias C.
Wolters, Paul J.
Hill, Maria L.
Frank, James A.
Brumwell, Alexis N.
Wheeler, Sarah E.
Kreidberg, Jordan A.
Chapman, Harold A.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) : 213 - 224
[8] The integrin αvβ6 binds and activates latent TGFβ1:: A mechanism for regulating pulmonary inflammation and fibrosis
Munger, JS
Huang, XZ
Kawakatsu, H
Griffiths, MJD
Dalton, SL
Wu, JF
Pittet, JF
Kaminski, N
Garat, C
Matthay, MA
Rifkin, DB
Sheppard, D
[J]. CELL, 1999, 96 (03) : 319 - 328
[9] A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis
Nagase, T
Uozumi, N
Ishii, S
Kita, Y
Yamamoto, H
Ohga, E
Ouchi, Y
Shimizu, T
[J]. NATURE MEDICINE, 2002, 8 (05) : 480 - 484
[10] Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β
Oga, Toru
Matsuoka, Toshiyuki
Yao, Chengcan
Nonomura, Kimiko
Kitaoka, Shiho
Sakata, Daiji
Kita, Yoshihiro
Tanizawa, Kiminobu
Taguchi, Yoshio
Chin, Kazuo
Mishima, Michiaki
Shimizu, Takao
Narumiya, Shuh
[J]. NATURE MEDICINE, 2009, 15 (12) : 1426 - U12

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