Post-CAR relapse in DLBCL: a fork in the road Comment

被引：6

作者：

Abramson, Jeremy S. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

BLOOD | 2022年 / 140卷 / 24期

关键词：

B-CELL LYMPHOMA;

D O I：

10.1182/blood.2022018295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Di Blasi et al highlight the transformational nature of chimeric antigen receptor (CAR) T cells, as well as the new unmet medical need in diffuse large B-cell lymphoma (DLBCL)-managing patients progressing after CAR T-cell therapy.1 Before the availability of CAR T cells, patients with chemotherapy-refractory DLBCL had an extremely low likelihood of response to conventional therapy and a life expectancy in the range of 6 months. Today, CART cells induce complete responses in approximately half of these patients, and long-term cure is approximately 40%.2 Di Blasi and colleagues use the French DESCAR-T (Dispositif d'Enregistrement et de Suivi des CAR-T) registry to assess the "real world " outcomes for 550 patients who received 1 of 2 available CAR T-cell products, axicabtagene cilolecuel or tisagenlecleucel, for multiply relapsed or refractory DLBCL.

引用

页码：2527 / 2529

页数：3

共 10 条

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