Synthesis of cyclic peptides constrained with biarylamine linkers using Buchwald-Hartwig C-N coupling

被引：27
|
作者：
Balraju, V.
Iqbal, Javed
机构：
[1] Dr Reddys Labs Ltd, Discovery Res, Hyderabad 500049, Andhra Pradesh, India
[2] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 23期
关键词：
D O I：
10.1021/jo061366i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, we describe the synthesis of conformationally constrained cyclic peptides with biarylamine linkers for peptidomimetics using palladium-catalyzed intramolecular Buchwald-Hartwig C-N coupling. We have prepared a variety of di-, tri-, and tetrapeptides (16-22-membered) in good yields using this reaction.
引用
收藏
页码：8954 / 8956
页数：3
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