Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory and antioxidant effects of Dysophylla stellata Benth.

被引：33

作者：

Gautam, Raju ^{[1
]}

Srivastava, Amit ^{[1
]}

Jachak, Sanjay M. ^{[1
]}

Saklani, Arvind ^{[1
]}

机构：

[1] NIPER, Dept Nat Prod, Mohali 160062, Punjab, India

来源：

FITOTERAPIA | 2010年 / 81卷 / 01期

关键词：

Dysophylla stellato; Anti-inflammatory; Cyclooxygenase (COX)-1; COX-2; Antioxidant; Stellatin; IMMUNOSTIMULATORY ACTIVITY; CASSIA-PETERSIANA; CHROMONES; CONSTITUENTS; MACROPHAGES; MICE;

D O I：

10.1016/j.fitote.2009.07.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The n-hexane and ethyl acetate extracts of whole plants of Dysophylla stellata significantly inhibited edema when applied topically at doses of 0.5 and 1 mg/ear in TPA-induced ear edema assay in mice. Further, both the extracts were evaluated for COX-1 and COX-2 inhibitory activities and showed 85.42 and 57.38%; and 71.79 and 89.27% inhibition at 50 mu g/ml, respectively. Chromones (1 and 2) present in these extracts could be responsible for their COX-1 and COX-2 inhibitory and anti-inflammatory activities. The ethyl acetate extract showed antioxidant activity in DPPH and ABTS radical scavenging assay where as n-hexane extract found to be inactive. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：45 / 49

页数：5

共 21 条

[1] Structural and functional basis of cyclooxygenase inhibition [J].