Cardiotoxicity Associated with Anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Recognition, Risk Factors, and Management

被引：32

作者：

Burns, Ethan A. ^{[1
]}

Gentille, Cesar ^{[1
]}

Trachtenberg, Barry ^{[2
]}

Pingali, Sai Ravi ^{[1
]}

Anand, Kartik ^{[3
]}

机构：

[1] Houston Methodist Hosp, Houston Methodist Canc Ctr, Outpatient Ctr, 6445 Main St,24th Floor, Houston, TX 77030 USA

[2] Houston Methodist DeBakey Heart & Vasc Ctr, 6565 Fannin St, Houston, TX 77030 USA

[3] Great Plains Hlth, Callahan Canc Ctr, 601 W Leota St, North Platte, NE 69101 USA

来源：

DISEASES | 2021年 / 9卷 / 01期

关键词：

CAR-T; cardiotoxicity; hypotension; heart failure; cytokine release syndrome; leukemia; lymphoma; CYTOKINE RELEASE SYNDROME; INTERLEUKIN-6; DIAGNOSIS; MYELOMA; ADULTS;

D O I：

10.3390/diseases9010020

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chimeric antigen receptor T-cells (CAR-T) are improving outcomes in pediatric and adult patients with relapsed or refractory B-cell acute lymphoblastic leukemias and subtypes of non-Hodgkin Lymphoma. As this treatment is being increasingly utilized, a better understanding of the unique toxicities associated with this therapy is warranted. While there is growing knowledge on the diagnosis and treatment of cytokine release syndrome (CRS), relatively little is known about the associated cardiac events that occur with CRS that may result in prolonged length of hospital stay, admission to the intensive care unit for pressor support, or cardiac death. This review focuses on the various manifestations of cardiotoxicity, potential risk factors, real world and clinical trial data on prevalence of reported cardiotoxicity events, and treatment recommendations.

引用

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