Emerging links between hypermutation of antibody genes and DNA polymerases

被引：43
作者：
Gearhart, PJ
Wood, RD
机构：
[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA
[2] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15261 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 03期
关键词：
D O I：
10.1038/35105009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Substantial antibody variability is created when nucleotide substitutions are introduced into immunoglobulin variable genes by a controlled process of hypermutation. Evidence points to a mechanism involving DNA repair events at sites of targeted breaks. In vertebrate cells, there are many recently identified DNA polymerases that inaccurately copy templates. Some of these are candidates for enzymes that introduce base changes during hypermutation. Recent research has focused on possible roles for DNA polymerases zeta (POLZ), eta (POLH), iota (POLI), and tau (POLM) in the process.
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页码：187 / 192
页数：6
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