Impact of HIV-1 Diversity on Its Sensitivity to Neutralization

被引：20

作者：

Stefic, Karl ^{[1
,2
]}

Bouvin-Pley, Melanie ^{[1
]}

Braibant, Martine ^{[1
]}

Barin, Francis ^{[1
,2
]}

机构：

[1] Univ Tours, Inserm U1259, F-37000 Tours, France

[2] CHRU Tours, Ctr Natl Reference VIH, Lab Associe, F-37000 Tours, France

来源：

VACCINES | 2019年 / 7卷 / 03期

关键词：

HIV-1; vaccine; broadly neutralizing antibodies; diversity; evolution; envelope; IMMUNODEFICIENCY-VIRUS TYPE-1; ANTIBODY-RESPONSE; MONOCLONAL-ANTIBODIES; DISEASE PROGRESSION; GLYCOSYLATION SITES; ELITE NEUTRALIZER; HUMORAL IMMUNITY; ENVELOPE; VACCINE; INFECTION;

D O I：

10.3390/vaccines7030074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important and challenging to overcome. The recent development of broadly neutralizing antibodies has considerably improved our knowledge on Env structure and its interplay with neutralizing antibodies. This review aims at highlighting how the genetic diversity of HIV-1 thwarts current, and possibly future, vaccine developments. We will focus on the impact of HIV-1 Env diversification on the sensitivity to neutralizing antibodies and the repercussions of this continuous process at a population level.

引用

页数：14

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