The influence of nanoparticulate drug delivery systems in drug therapy

The advancement in medical sciences and perturbing limitations of some conventional drug delivery systems have triggered extensive research in nanomedicine, and there have been profound exploitations that promise to revolutionise drug delivery systems. To develop more effective and safer therapeutic medicines, researchers have designed various advanced and multifunctional nanocarrier systems that can provide targeted, sustained, and controlled delivery of drugs. These novel systems are leading to the enhancement of drugs' systemic circulation, improvement of the pharmacokinetic profile of drugs, and reduction of adverse effect incidences of drugs. Some of the nanoparticulate drug delivery systems that have demonstrated substantial benefits such as polymeric, lipids and metals nanoparticles; liposomes; nanoemulsions; and micelles have already made it to the market. These nanocarriers have greatly influenced the pattern of modern drug therapy to address emerging needs. However, there are some concerns related to toxicological aspects associated with some of these nanocarriers that need to be resolved. This review article was aimed to provide insightful advancements on the applications of nanoparticulate drug delivery systems in the treatment of range of diseases in modern therapeutics. Particular emphasis was given to the roles of these nanocarriers in overcoming the prompted limitations of conventional drug delivery systems.