Iridium-Catalyzed Regioselective C(sp3)-H Silylation of 4-Alkylpyridines at the Benzylic Position with Hydrosilanes Leading to 4-(1-Silylalkyl)pyridines

被引：31

作者：

Fukumoto, Yoshiya ^{[1
]}

Hirano, Masaya ^{[1
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

ACS CATALYSIS | 2017年 / 7卷 / 05期

关键词：

C-H functionalization; silylation; 4-alkylpyridine; hydrosilane; iridium catalyst; C-H SILYLATION; TRANSITION-METAL-COMPLEXES; DEHYDROGENATIVE SILYLATION; AROMATIC-SUBSTITUTION; DIHYDROGEN COMPLEXES; BOND ACTIVATION; ARENES; FUNCTIONALIZATION; PALLADIUM; PYRIDINES;

D O I：

10.1021/acscatal.7b00539

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The regioselective silylation of C(sp(3))-H bonds at the benzylic position in 4-alkylpyridines with hydrosilanes is described. The reaction proceeds in the presence of a catalytic amount of Ir-4(CO)(12) or Ir(acac)(CO)(2), which possess CO as a ligand, or [Ir(OMe)(cod)](2) under 1 atm of CO. After optimizing the reaction conditions, by using other pyridine derivatives, such as 3,5-dimethylpyridine, as additives, the low product yields of 2-substituted 4-methylpyridines were improved markedly.

引用

收藏

页码：3152 / 3156

页数：5

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