Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens

被引：32

作者：

Gao, Xin-Hua ^{[1
]}

Fan, Yao-Yue ^{[1
]}

Liu, Qun-Fang ^{[1
]}

Cho, Sang-Hyun ^{[2
]}

Pauli, Guido F. ^{[2
]}

Chen, Shao-Nong ^{[2
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China

[2] Univ Illinois, Coll Pharm, Inst TB Res, 833 South Wood St, Chicago, IL 60612 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 17期

基金：

中国国家自然科学基金;

关键词：

CYTOTOXIC INDOLE ALKALOIDS; BISINDOLE ALKALOIDS; NATURAL-PRODUCTS; CRYSTALLOGRAPHY;

D O I：

10.1021/acs.orglett.9b02630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The suadimins A-C (1-3) from Melodinus suaveolens are the first example of monoterpenoid quinoline alkaloid dimers featuring an unprecedented carbon skeleton. Their structures and absolute configurations were established on the basis of extensive spectroscopic analyses, electric circular dichroism (ECD), and X-ray crystallography. Suadimin A showed significant antimycobacterial activity in vitro with an MIC90 of 6.76 mu M against the H(37)Rv strain of M. tuberculosis.

引用

页码：7065 / 7068

页数：4

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