Phospholipase D in the Golgi apparatus

被引：31

作者：

Riebeling, Christian ^{[1
]}

Morris, Andrew J. ^{[3
]}

Shields, Dennis ^{[1
,2
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[3] Gill Heart Inst, Div Cardiovasc Med, Lexington, KY 40536 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Phospholipase D; Phosphatidic acid; Golgi apparatus; Vesicular trafficking; ADP-RIBOSYLATION FACTOR; EPIDERMAL-GROWTH-FACTOR; PHOSPHATIDIC-ACID; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PLASMA-MEMBRANE; IN-VITRO; SACCHAROMYCES-CEREVISIAE; DIFFERENTIAL REGULATION; EPITHELIAL-CELLS; COATED VESICLES;

D O I：

10.1016/j.bbalip.2009.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo. Phospholipase D has been found on the Golgi apparatus and is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking. Moreover, the product of phospholipase D activity, phosphatidic acid, as well as its degradation product diacylglycerol, have been implicated in vesicle fission and fusion events. Here we summarize recent advances in the understanding of the role of phospholipase D at the Golgi apparatus. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：876 / 880

页数：5

共 82 条

[1] The role of phospholipase D in plant stress responses [J].