Serum endothelial cell specific molecule-1 (endocan) levels in patients with obstructive sleep apnea

被引：12

作者：

Bingol, Zuleyha ^{[1
]}

Kose, Murat ^{[2
]}

Pihtili, Aylin ^{[3
]}

Akpinar, Timur ^{[2
]}

Tukek, Tufan ^{[2
]}

Kiyan, Esen ^{[1
,2
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Pulm Med, TR-34360 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Dept Internal Med, TR-34360 Istanbul, Turkey

[3] Istanbul Haydarpasa Numune Training & Res Hosp, Dept Pulm Med, TR-34668 Istanbul, Turkey

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 02期

关键词：

endocan; endothelial cell-specific molecule-1; endothelial dysfunction; obstructive sleep apnea; CARDIOVASCULAR RISK; ESM-1; OVEREXPRESSION; ANGIOGENESIS; HYPERTENSION; EXPRESSION; SURVIVAL; DISEASE; MARKER; LUNG;

D O I：

10.2217/bmm.15.117

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To investigate the level of endothelial cell specific molecule-1 (endocan) in obstructive sleep apnea (OSA). Methods: Study group included subjects with OSA. Control group included subjects who had no OSA on polysomnography and nonobese healthy subjects from population who had no OSA symptoms. Endocan levels of OSA and non-OSA subjects were compared. Results: Totally 106 individuals (63 OSA, 43 non-OSA) were included. Endocan levels were higher in OSA subjects than controls (1.25 +/- 0.4 ng/ml vs 0.93 +/- 0.3 ng/ml, p < 0.001). Endocan levels were correlated with BMI (r = 0.456, p < 0.001) and daytime PaO2 (r = -0.266, p < 0.042). In linear regression analysis there was no factor related to endocan level. Conclusion: Serum endocan is significantly higher in OSA. Further studies should be performed to better understand the relationship between endocan and OSA.

引用

页码：177 / 184

页数：8

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