Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

被引：107

作者：

Elkhoury, Kamil ^{[1
]}

Russell, Carina S. ^{[2
]}

Sanchez-Gonzalez, Laura ^{[1
]}

Mostafavi, Azadeh ^{[2
]}

Williams, Tyrell J. ^{[2
]}

Kahn, Cyril ^{[1
]}

Peppas, Nicholas A. ^{[3
,4
,5
,6
]}

Arab-Tehrany, Elmira ^{[1
]}

Tamayol, Ali ^{[2
,7
]}

机构：

[1] Univ Lorraine, LIBio, F-54000 Nancy, France

[2] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68508 USA

[3] Univ Texas Austin, Dept Biomed Engn, Dell Med Sch, Dept Pediat, Austin, TX 78712 USA

[4] Univ Texas Austin, Dept Chem Engn, Dell Med Sch, Dept Pediat, Austin, TX 78712 USA

[5] Univ Texas Austin, Dept Biomed Engn, Dell Med Sch, Dept Surg, Austin, TX 78712 USA

[6] Univ Texas Austin, Dept Chem Engn, Dell Med Sch, Dept Surg, Austin, TX 78712 USA

[7] Univ Nebraska Med Ctr, Mary & Dick Holland Regenerat Med Program, Omaha, NE 68198 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2019年 / 8卷 / 18期

基金：

美国国家卫生研究院;

关键词：

nanofunctionalization; natural hydrogels; soft nanoparticles; tissue engineering; DRUG-DELIVERY SYSTEMS; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; BONE TISSUE; IN-VITRO; MECHANICAL-PROPERTIES; BIOMEDICAL APPLICATIONS; RECOGNITIVE SYSTEMS; IMPRINTED POLYMERS; GOLD NANOPARTICLES;

D O I：

10.1002/adhm.201900506

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

引用

页数：14

共 193 条

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