The distinct distribution and phylogenetic characteristics of dengue virus serotypes/genotypes during the 2013 outbreak in Yunnan, China Phylogenetic characteristics of 2013 dengue outbreak in Yunnan, China

被引：31

作者：

Wang, Binghui ^{[1
]}

Yang, Henglin ^{[2
]}

Feng, Yue ^{[1
]}

Zhou, Hongning ^{[2
]}

Dai, Jiejie ^{[3
,4
]}

Hu, Yunzhang ^{[3
,4
]}

Zhang, Li ^{[1
]}

Wang, Yajuan ^{[1
]}

Baloch, Zulqarnain ^{[1
]}

Xia, Xueshan ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Ctr Mol Med Yunnan Prov, Kunming, Yunnan, Peoples R China

[2] Yunnan Res Inst Parasit Dis Control, Kunming, Yunnan, Peoples R China

[3] Chinese Acad Med Sci, Inst Mol Biol, Kunming, Yunnan, Peoples R China

[4] Peking Union Med Coll, Kunming, Yunnan, Peoples R China

来源：

INFECTION GENETICS AND EVOLUTION | 2016年 / 37卷

基金：

中国国家自然科学基金;

关键词：

Dengue; Outbreak; Phylogenetic analysis; Bayesian analysis; Imported infection; MOLECULAR EVOLUTION; TYPE-1; EPIDEMIOLOGY; REVEALS;

D O I：

10.1016/j.meegid.2015.10.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since 2000, sporadic imported cases of dengue fever were documented almost every year in Yunnan Province, China. Unexpectedly, a large-scale outbreak of dengue virus (DENV) infection occurred from August to December 2013, with 1538 documented cases. In the current study, 81 dengue-positive patient samples were collected from Xishuangbanna, the southernmost prefecture of the Yunnan province, and 23 from Dehong, the westernmost prefecture of the Yunnan province. The full-length envelope genes were amplified and sequenced. Phylogenetic analysis revealed that nine strains (39.1%) and 14 strains (60.9%) from the Dehong prefecture were classified as genotype I of DENV-1 and Asian I genotype of DENV-2, respectively. All strains from Xishuangbanna were identified as genotype II of DENV-3. Bayesian coalescent analysis indicates that the outbreak originated from bordering southeastern Asian countries. These three epidemic genotypes were predicted to originate in Thailand and then migrate into Yunnan through different routes. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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