YADA: a tool for taking the most out of high-resolution spectra

被引:62
作者
Carvalho, Paulo C. [1 ,2 ]
Xu, Tao [2 ]
Han, Xuemei [2 ]
Cociorva, Daniel [2 ]
Barbosa, Valmir C. [1 ]
Yates, John R., III [2 ]
机构
[1] Univ Fed Rio de Janeiro, COPPE, Syst Engn & Comp Sci Program, BR-21941972 Rio De Janeiro, Brazil
[2] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
基金
美国国家卫生研究院;
关键词
TANDEM MASS-SPECTRA; PROTEIN IDENTIFICATION; SPECTROMETRY; DATABASE;
D O I
10.1093/bioinformatics/btp489
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
YADA can deisotope and decharge high-resolution mass spectra from large peptide molecules, link the precursor monoisotopic peak information to the corresponding tandem mass spectrum, and account for different co-fragmenting ion species (multiplexed spectra). We describe how YADA enables a pipeline consisting of ProLuCID and DTASelect for analyzing large-scale middle-down proteomics data.
引用
收藏
页码:2734 / 2736
页数:3
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