Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population

被引:29
作者
Kim, Won
Choi, Young Hee
Yoon, Kyung-Sik
Cho, Dae-Yeon
Pae, Chi-Un
Woo, Jong-Min
机构
[1] Inje Univ, Seoul Pk Hosp, Dept Neuropsychiat, Seoul 100032, South Korea
[2] Inje Univ, Seoul Pk Hosp, Stress Res Inst, Seoul 100032, South Korea
[3] Mettaa Inst Cognit Behav Therapy & Psychiat, Seoul, South Korea
[4] Kyung Hee Univ, Sch Med, Dept Biochem & Mol Biol, Seoul, South Korea
[5] LabGenom Clin Res Inst, Seoul, South Korea
[6] Catholic Univ Korea, Kangnam St Marys Hosp, Dept Psychiat, Seoul, South Korea
关键词
Korean; panic disorder; polymorphism; scrotonin transporter gene; tryptophan hydroxylase gene;
D O I
10.1016/j.pnpbp.2006.05.017
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Panic disorder may be associated with defective scrotonin (5-HT) neurotransmission. This study was to investigate the association between the tryptophan hydroxylase (TPH) gene and a serotonin transporter gene promoter polymorphism (5-HTTLPR), with panic disorder in a Korean population. 244 Korean patients with panic disorder and the 227 controls were genotyped by a polymerase chain reaction-based method. The severity of panic disorders was assessed by number of panic attacks during the previous. I month, as well as scores for anticipatory anxiety, panic distress, and agoraphobic distress, as determined by a visual analogue scale (VAS). All the subjects completed the assessment measures including Spielberger State-Trait Anxiety Inventory-State (STAI-S), Spielberger State-Trait Anxiety Inventory-Trait (STAI-T), Beck Depression Inventory (BDI), Symptom Checklist-90-Revised (SCL-90-R), Revised Anxiety Sensitivity Index (ASI-R), Clinical Global Impression Scale - Severity of Illness (CGI-S), Panic Disorder Severity Scale (PDSS), and the Hamilton Depression Rating Scale (HAMD). Responder analyses were conducted based on changes in CGI-I scores after 10 weeks of treatment. We found no significant differences in the genotype and allele frequencies in TPH A218C and 5-HTTLPR polymorphisms between the panic patients and the control group. Subgroup analyses in terms of comorbidities, response, and other primary clinical variables, indicated no differences in these polymorphisms. Our findings suggest that the TPH A218C polymorphism and 5-HTTLPR play no significant roles in the pathogenesis and clinical symptomatologies, at least in a Korean population. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:1413 / 1418
页数:6
相关论文
共 44 条
[21]   Serotonin function in panic disorder: Important, but why? [J].
Maron, E ;
Shlik, J .
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (01) :1-11
[22]   Serotonin transporter gene regulatory region polymorphism and panic disorder [J].
Matsushita, S ;
Muramatsu, T ;
Kimura, M ;
Shirakawa, O ;
Mita, T ;
Nakai, T ;
Higuchi, S .
MOLECULAR PSYCHIATRY, 1997, 2 (05) :390-391
[23]   Role of the serotonin transporter promoter polymorphism in anxiety-related traits [J].
Mazzanti, CM ;
Lappalainen, J ;
Long, JC ;
Bengel, D ;
Naukkarinen, H ;
Eggert, M ;
Virkkunen, M ;
Linnoila, M ;
Goldman, D .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (10) :936-940
[24]   Diagnostic and Statistical Manual of Mental Disorders [J].
Mittal, Vijay A. ;
Walker, Elaine F. .
PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159
[25]   Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels [J].
Nakamura, K ;
Sugawara, Y ;
Sawabe, K ;
Ohashi, A ;
Tsurui, H ;
Xiu, Y ;
Ohtsuji, M ;
Lin, QS ;
Nishimura, H ;
Hasegawa, H ;
Hirose, S .
JOURNAL OF NEUROSCIENCE, 2006, 26 (02) :530-534
[26]  
NOYES R, 1986, ARCH GEN PSYCHIAT, V43, P227
[27]   The short/long polymorphism in the serotonin transporter gene promoter is not associated with panic disorder in a Scandinavian sample [J].
Olesen, OF ;
Bennike, B ;
Hansen, ES ;
Koefoed, P ;
Woldbye, DP ;
Bolwig, TG ;
Mellerup, E .
PSYCHIATRIC GENETICS, 2005, 15 (03) :159-159
[28]   Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland [J].
Patel, PD ;
Pontrello, C ;
Burke, S .
BIOLOGICAL PSYCHIATRY, 2004, 55 (04) :428-433
[29]   Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene [J].
Perna, G ;
Favaron, E ;
Di Bella, D ;
Bussi, R ;
Bellodi, L .
NEUROPSYCHOPHARMACOLOGY, 2005, 30 (12) :2230-2235
[30]   Panic attacks: A twin study [J].
Perna, G ;
Caldirola, D ;
Arancio, C ;
Bellodi, L .
PSYCHIATRY RESEARCH, 1997, 66 (01) :69-71