Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

被引：46

作者：

Hawk, Mark A. ^{[1
]}

McCallister, Chelsea ^{[1
]}

Schafer, Zachary T. ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA

来源：

CANCERS | 2016年 / 8卷 / 10期

基金：

美国国家科学基金会;

关键词：

antioxidant; reactive oxygen species; extracellular matrix; NADPH; Nrf2; pentose phosphate pathway; metastasis; PYRUVATE-KINASE; METABOLISM; GLUTATHIONE; M2;

D O I：

10.3390/cancers8100092

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antioxidant defenses encompass a variety of distinct compounds and enzymes that are linked together through their capacity to neutralize and scavenge reactive oxygen species (ROS). While the relationship between ROS and tumorigenesis is clearly complex and context dependent, a number of recent studies have suggested that neutralizing ROS can facilitate tumor progression and metastasis in multiple cancer types through distinct mechanisms. These studies therefore infer that antioxidant activity may be necessary to support the viability and/or the invasive capacity of cancer cells during tumor progression and metastasis. Here, we discuss some of the accumulating evidence suggesting a role for antioxidant activity in facilitating tumor progression.

引用

页数：6

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