Should Controls With Respiratory Symptoms Be Excluded From Case-Control Studies of Pneumonia Etiology? Reflections From the PERCH Study

被引：20

作者：

Higdon, Melissa M. ^{[1
]}

Hammitt, Laura L. ^{[1
,2
]}

Knoll, Maria Deloria ^{[1
]}

Baggett, Henry C. ^{[3
,4
]}

Brooks, W. Abdullah ^{[5
,6
,7
]}

Howie, Stephen R. C. ^{[8
,9
,10
]}

Kotloff, Karen L. ^{[11
]}

Levine, Orin S. ^{[1
,12
]}

Madhi, Shabir A. ^{[13
,14
]}

Murdoch, David R. ^{[15
,16
]}

Scott, J. Anthony G. ^{[2
,17
]}

Thea, Donald M. ^{[18
]}

Driscoll, Amanda J. ^{[1
]}

Karron, Ruth A. ^{[11
,19
]}

Park, Daniel E. ^{[1
,20
]}

Prosperi, Christine ^{[1
]}

Zeger, Scott L. ^{[21
]}

O'Brien, Katherine L. ^{[1
]}

Feikin, Daniel R. ^{[1
,22
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Int Vaccine Access Ctr, Dept Int Hlth, 415 N Washington St,Rm 561, Baltimore, MD 21231 USA

[2] Kenya Govt Med Res Ctr, Wellcome Trust Res Programme, Kilifi, Kenya

[3] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Health, Global Dis Detect Ctr, Nonthaburi, Thailand

[4] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA USA

[5] Bangladesh Icddr B, Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh

[6] Bangladesh Icddr B, Int Ctr Diarrhoeal Dis Res, Matlab, Bangladesh

[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA

[8] MRC Unit, Basse, Gambia

[9] Univ Auckland, Dept Paediat, Dunedin, New Zealand

[10] Univ Otago, Ctr Int Hlth, Dunedin, New Zealand

[11] Univ Maryland, Sch Med, Inst Global Hlth,Dep Pediat, Ctr Vaccine Dev,Div Infect Dis & Trop Pediat, Baltimore, MD 21201 USA

[12] Bill & Melinda Gates Fdn, Seattle, WA USA

[13] Univ Witwatersrand, Med Res Council, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa

[14] Univ Witwatersrand, Vaccine Preventable Dis Unit, Natl Res Fdn, Dept Sci & Technol, Johannesburg, South Africa

[15] Univ Otago, Dept Pathol, Christchurch, New Zealand

[16] Canterbury Hlth Labs, Microbiol Unit, Christchurch, New Zealand

[17] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England

[18] Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA USA

[19] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD USA

[20] George Washington Univ, Milken Inst Sch Publ Hlth, Dept Epidemiol & Biostat, Washington, DC USA

[21] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[22] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2017年 / 64卷

基金：

比尔及梅琳达.盖茨基金会; 英国惠康基金;

关键词：

PERCH; control selection; respiratory symptoms; pneumonia etiology; selection bias; PNEUMOCOCCAL CONJUGATE VACCINE; COMMUNITY-ACQUIRED PNEUMONIA; CHILDHOOD PNEUMONIA; BACTERIAL PNEUMONIA; CHILDREN; HEALTH; HOSPITALIZATION; COUNTRIES; PROTOCOL; VIRUSES;

D O I：

10.1093/cid/cix076

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many pneumonia etiology case-control studies exclude controls with respiratory illness from enrollment or analyses. Herein we argue that selecting controls regardless of respiratory symptoms provides the least biased estimates of pneumonia etiology. We review 3 reasons investigators may choose to exclude controls with respiratory symptoms in light of epidemiologic principles of control selection and present data from the Pneumonia Etiology Research for Child Health (PERCH) study where relevant to assess their validity. We conclude that exclusion of controls with respiratory symptoms will result in biased estimates of etiology. Randomly selected community controls, with or without respiratory symptoms, as long as they do not meet the criteria for case-defining pneumonia, are most representative of the general population from which cases arose and the least subject to selection bias.

引用

页码：S205 / S212

页数：8

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