Molecular mechanisms of Escherichia coli pathogenicity

被引：828

作者：

Croxen, Matthew A. ^{[1
]}

Finlay, B. Brett ^{[1
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 01期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

DECAY-ACCELERATING FACTOR; HEAT-LABILE ENTEROTOXIN; PROTEIN-A RECEPTOR; NF-KAPPA-B; SHIGA-TOXIN; EPITHELIAL-CELLS; URINARY-TRACT; MITOCHONDRIAL DYSFUNCTION; INFLAMMATORY RESPONSE; ACTIN POLYMERIZATION;

D O I：

10.1038/nrmicro2265

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Escherichia coli is a remarkable and diverse organism. This normally harmless commensal needs only to acquire a combination of mobile genetic elements to become a highly adapted pathogen capable of causing a range of diseases, from gastroenteritis to extraintestinal infections of the urinary tract, bloodstream and central nervous system. The worldwide burden of these diseases is staggering, with hundreds of millions of people affected annually. Eight E. coli pathovars have been well characterized, and each uses a large arsenal of virulence factors to subvert host cellular functions to potentiate its virulence. In this Review, we focus on the recent advances in our understanding of the different pathogenic mechanisms that are used by various E. coli pathovars and how they cause disease in humans.

引用

页码：26 / 38

页数：13

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