Natural killer cells in inflammatory autoimmune diseases

被引：47

作者：

Yang, Yuyan ^{[1
,2
]}

Day, Jessica ^{[2
,3
,4
]}

Souza-Fonseca Guimaraes, Fernando ^{[5
]}

Wicks, Ian P. ^{[2
,3
,4
]}

Louis, Cynthia ^{[2
,3
]}

机构：

[1] Tsinghua Univ, Sch Med, Beijing, Peoples R China

[2] Walter & Eliza Hall Inst Med Res, Inflammat Div, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Med Biol, Melbourne, Vic, Australia

[4] Royal Melbourne Hosp, Rheumatol Unit, Parkville, Vic, Australia

[5] Univ Queensland, Diamantina Inst, Woolloongabba, Qld, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2021年 / 10卷 / 02期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

natural killer cells; autoimmune disease; rheumatoid arthritis; multiple sclerosis; systemic lupus erythematosus; type 1 diabetes mellitus; idiopathic inflammatory myopathies; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HUMAN NK CELLS; PLASMACYTOID DENDRITIC CELLS; IMMUNOGLOBULIN-LIKE RECEPTORS; MULTIPLE-SCLEROSIS; PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; CUTTING EDGE; BETA-CELLS;

D O I：

10.1002/cti2.1250

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof-of-concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell-targeted therapeutics.

引用

页数：17

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