Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance

被引：54

作者：

Nardy, Ana F. F. R. ^{[1
]}

Freire-de-Lima, Celio G. ^{[2
]}

Perez, Ana R. ^{[3
]}

Morrot, Alexandre ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Microbiol, Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Carlos Chagas Filho Inst Biophys, Rio De Janeiro, Brazil

[3] Natl Univ Rosario, CONICET, Inst Clin & Expt Immunol Rosari, Rosario, Santa Fe, Argentina

来源：

FRONTIERS IN MICROBIOLOGY | 2016年 / 7卷

关键词：

Trypanosoma cruzi; trans-sialidase; parasites; immune evasion; glycoimmunology; ACUTE-PHASE ANTIGEN; T-CELL-ACTIVATION; THYMUS ATROPHY; CHAGAS-DISEASE; CRYSTAL-STRUCTURE; ACID; INVASION; BINDING; NEURAMINIDASE; SIALYLATION;

D O I：

10.3389/fmicb.2016.00348

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T cruzi infection.

引用

页数：9

共 50 条

[21] Effect of primary structure modifications in Trypanosoma cruzi neuraminidase/trans-sialidase activities [J].

Cremona, ML ;

Pollevick, GD ;

Frasch, ACC ;

Campetella, O .

CELLULAR AND MOLECULAR BIOLOGY, 1996, 42 (05) :697-702

[22] Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol [J].

Eugenia Giorgi, M. ;

Ratier, Laura ;

Agusti, Rosalia ;

Frasch, Alberto C. C. ;

de Lederkremer, Rosa M. .

GLYCOBIOLOGY, 2012, 22 (10) :1363-1373

[23] In vivo infection by Trypanosoma cruzi: The conserved FLY domain of the gp85/trans-sialidase family potentiates host infection [J].

Tonelli, R. R. ;

Torrecilhas, A. C. ;

Jacysyn, J. F. ;

Juliano, M. A. ;

Colli, W. ;

Alves, M. J. M. .

PARASITOLOGY, 2011, 138 (04) :481-492

[24] Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi [J].

Bontempi, Ivan ;

Fleitas, Pedro ;

Poato, Alexia ;

Vicco, Miguel ;

Rodeles, Luz ;

Prochetto, Estefania ;

Cabrera, Gabriel ;

Beluzzo, Bruno ;

Arias, Diego ;

Racca, Andrea ;

Guerrero, Sergio ;

Marcipar, Ivan .

IMMUNOTHERAPY, 2017, 9 (07) :555-565

[25] Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase [J].

Arioka, Shingo ;

Sakagami, Masahiro ;

Uematsu, Rie ;

Yamaguchi, Hiroto ;

Togame, Hiroko ;

Takemoto, Hiroshi ;

Hinou, Hiroshi ;

Nishimura, Shin-ichiro .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (04) :1633-1640

[26] Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes [J].

Nardy, Ana Flavia F. R. ;

da Silva Filho, Joao Luiz ;

Perez, Ana Rosa ;

de Meis, Juliana ;

Farias-de-Oliveira, Desio Aurelio ;

Penha, Luciana ;

Oliveira, Isadora de Araujo ;

Dias, Wagner B. ;

Todeschini, Adriane R. ;

Freire-de-Lima, Celio Geraldo ;

Bellio, Maria ;

Caruso-Neves, Celso ;

Pinheiro, Ana Acacia ;

Takiya, Christina Maeda ;

Bottasso, Oscar ;

Savino, Wilson ;

Morrot, Alexandre .

MICROBES AND INFECTION, 2013, 15 (05) :365-374

[27] Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites [J].

Burle-Caldas, Gabriela de A. ;

dos Santos, Nailma S. A. ;

de Castro, Julia T. ;

Mugge, Fernanda L. B. ;

Grazielle-Silva, Viviane ;

Oliveira, Antonio Edson R. ;

Pereira, Milton C. A. ;

Reis-Cunha, Joo Luis ;

dos Santos, Anderson Coqueiro ;

Gomes, Dawidson Assis ;

Bartholomeu, Daniella C. ;

Moretti, Nilmar S. ;

Schenkman, Sergio ;

Gazzinelli, Ricardo T. ;

Teixeira, Santuza M. R. .

MBIO, 2022, 13 (01)

[28] Synthesis and Characterization of Sialylated Lactose- and Lactulose-Derived Oligosaccharides by Trypanosoma cruzi Trans-sialidase [J].

Pham, Hien T. T. ;

ten Kate, Geert A. ;

Dijkhuizen, Lubbert ;

van Leeuwen, Sander S. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (12) :3469-3479

[29] trans-sialidase of Trypanosoma cruzi:: Location of galactose-binding site(s) [J].

Chuenkova, M ;

Pereira, M ;

Taylor, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 262 (02) :549-556

[30] Development of New and Selective Trypanosoma cruzi trans-Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives [J].

Kim, Jin Hyo ;

Ryu, Hyung Won ;

Shim, Jae Hoon ;

Park, Ki Hun ;

Withers, Stephen G. .

CHEMBIOCHEM, 2009, 10 (15) :2475-2479

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