Porcine allergy and IgE

被引:16
作者
Rupa, Prithy [1 ]
Schmied, Julie [1 ]
Wilkie, Bruce N. [1 ]
机构
[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON N1G 2W1, Canada
关键词
Pig; Allergy; IgE; NEONATAL SWINE MODEL; IMMEDIATE HYPERSENSITIVITY; DIETARY ANTIGEN; PIGS; ANTIBODY; METASTRONGYLUS; PATHOGENESIS; INFECTIONS; DIARRHEA; RELEASE;
D O I
10.1016/j.vetimm.2009.09.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anaphylaxis was reported in 1963 in pigs experimentally sensitized with ovalbumin and was subsequently associated indirectly with IgE-related antibodies by functional assays to confirm heat-labile passive cutaneous anaphylaxis (PCA), reverse passive anaphylaxis (RPA) and Prausnitz-Kustner (PK) reactions to this and other allergens. The immunoglobulin mediating immediate hypersensitivity could be cross-adsorbed with anti-human IgE. Porcine IgE epsilon chain has been cloned and sequenced. Rabbit anti-pig IgE has been described by two groups, as has cross reactivity with pig IgE of various heterologous polyclonal and monoclonal anti-IgEs. Pigs develop transient post-weaning food allergy to soy allergens which can be prevented by pre-weaning feeding of soy proteins in sufficient quantity. Natural hypersensitivity also occurs to nematodes. Recently, experimental allergy has been induced in outbred pigs to peanut and to egg allergens which manifest as respiratory, cutaneous and enteric signs similar to those of human food allergy. These models are platforms for comparative allergy research as realistic alternatives to use of inbred mice or humans for investigation of pathogenesis, prophylaxis and therapy. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:41 / 45
页数:5
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