The role of angiogenesis in solid tumours: An overview

被引：113

作者：

Makrilia, Nektaria ^{[1
]}

Lappa, Theodora ^{[1
]}

Xyla, Vassilia ^{[1
]}

Nikolaidis, Ilias ^{[1
]}

Syrigos, Kostas ^{[1
]}

机构：

[1] Sotiria Gen Hosp, Athens Sch Med, Dept Med 3, Oncol Unit, Athens, Greece

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2009年 / 20卷 / 07期

关键词：

Angiogenesis; Bevacizumab; Targeted therapy; Tumour vasculature; ENDOTHELIAL GROWTH-FACTOR; E-CADHERIN EXPRESSION; THYMIDINE PHOSPHORYLASE EXPRESSION; TYROSINE KINASE INHIBITOR; CLINICAL-SIGNIFICANCE; PANCREATIC-CANCER; COLORECTAL-CANCER; CELL GROWTH; PROGNOSTIC-SIGNIFICANCE; ANTIANGIOGENIC THERAPY;

D O I：

10.1016/j.ejim.2009.07.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis is the physiological process of the formation of new blood vessels from pre-existing ones. Multiple molecules regulate angiogenesis, such as the vascular endothelial growth factor, angiopoietins, the fibroblast growth factor, the platelet-derived growth factor and the transforming growth factor-beta. Angiogenesis plays an important role in the growth, progression and metastasis of a tumour. Inhibiting the angiogenic process or targeting existing tumour vessels can be used for treatment of tumours as an alternative or in parallel with conventional chemotherapy. Many anti-angiogenic factors are under investigation and some are already being used in clinical practice with various results. (C) 2009 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

引用

页码：663 / 671

页数：9

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