Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

被引：47
作者：
Francisqueti-Ferron, Fabiane Valentini [1 ]
Togneri Ferron, Artur Junio [1 ]
Garcia, Jessica Leite [1 ]
Vagula de Almeida Silva, Carol Cristina [1 ]
Costa, Mariane Rovero [1 ]
Gregolin, Cristina Schmitt [1 ]
Moreto, Fernando [1 ]
Ferreira, Ana Lucia A. [1 ]
Minatel, Igor Otavio [2 ]
Correa, Camila Renata [1 ]
机构：
[1] Sao Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, Brazil
[2] Sao Paulo State Univ, Inst Biosci, BR-18618689 Botucatu, SP, Brazil
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 13期
基金：
巴西圣保罗研究基金会;
关键词：
Nrf2; age-related disorders; oxidative stress; NAD(P)H-QUINONE OXIDOREDUCTASE ACTIVITY; INDUCED OXIDATIVE STRESS; YA-SUBUNIT GENE; ALZHEIMERS-DISEASE; SYNUCLEIN AGGREGATION; INDUCIBLE EXPRESSION; THERAPEUTIC TARGET; INSULIN-RESISTANCE; 2-RELATED FACTOR; PATHWAY;
D O I：
10.3390/ijms20133208
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.
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页数：14
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