Umpolung Amination: Nickel-Catalyzed Coupling Reactions of N,N-Dialkyl-N-chloroamines with Diorganozinc Reagents

被引：151

作者：

Barker, Timothy J. ^{[1
]}

Jarvo, Elizabeth R. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 43期

关键词：

ELECTROPHILIC AMINATION; REDUCTIVE ELIMINATION; COPPER; REACTIVITY; HALIDES;

D O I：

10.1021/ja907038b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N,N-Dialkyl-N-chloroamines are an effective source of electrophilic nitrogen for nickel-catalyzed coupling with diarylzinc reagents. A variety of N-chloroamines as well as organozinc reagents react smoothly under the reaction conditions. A one-pot procedure that circumvents the need to isolate the N-chloroamines is described.

引用

页码：15598 / +

页数：3

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