Umpolung Amination: Nickel-Catalyzed Coupling Reactions of N,N-Dialkyl-N-chloroamines with Diorganozinc Reagents

被引：151
作者：
Barker, Timothy J. [1 ]
Jarvo, Elizabeth R. [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 43期
关键词：
ELECTROPHILIC AMINATION; REDUCTIVE ELIMINATION; COPPER; REACTIVITY; HALIDES;
D O I：
10.1021/ja907038b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N,N-Dialkyl-N-chloroamines are an effective source of electrophilic nitrogen for nickel-catalyzed coupling with diarylzinc reagents. A variety of N-chloroamines as well as organozinc reagents react smoothly under the reaction conditions. A one-pot procedure that circumvents the need to isolate the N-chloroamines is described.
引用
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页码：15598 / +
页数：3
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