Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

被引：23

作者：

Cairrao, MAR

Ribeiro, AM

Pizzo, AB

Fontana, ACK

Beleboni, RO

Coutinho-Netto, J

Miranda, A

Santos, WF

机构：

[1] Univ Sao Paulo, Lab Neurobiol & Peconhas, Dept Biol, Fac Filosofia,Ciencias & Letras Ribeirao Preto, BR-14049901 Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Lab Neuroquim, Dept Bioquim, BR-14049901 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil

来源：

PHARMACEUTICAL BIOLOGY | 2002年 / 40卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

anticonvulsant; bicuculline; GABA; GABA uptake; Parawixia bistriata; pentilenetetrazole; picrotoxin; Scaptocosa raptoria; spider venom; rat synaptosomes;

D O I：

10.1076/phbi.40.6.472.8436

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. The venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.

引用

页码：472 / 477

页数：6

共 4 条

[1] Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae)
Liberato, Jose Luiz
Siqueira Cunha, Alexandra Olimpio
Mortari, Marcia Renata
Gelfuso, Erica Apayecia
Beleboni, Rene de Oliueira
Coutinho-Netto, Joaquim
dos Santos, Wagner Ferreira
BRAIN RESEARCH, 2006, 1124 : 19 - 27
[2] Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae)
Fachim, Helene Aparecida
Siqueira Cunha, Alexandra Olimpio
Pereira, Adriana Colsera
Beleboni, Rene Oliveira
Gobbo-Neto, Leonardo
Lopes, Norberto Peporine
Coutinho-Netto, Joaquim
dos Santos, Wagner Ferreira
EPILEPSY & BEHAVIOR, 2011, 22 (02) : 158 - 164
[3] Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures
Primini, Eduardo Octaviano
Liberato, Jose Luiz
Karklin Fontana, Andreia Cristina
dos Santos, Wagner Ferreira
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2019, 25
[4] Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Gelfuso, Erica A.
Liberato, Jose L.
Cunha, Alexandra O. S.
Mortari, Marcia R.
Beleboni, Rene O.
Lopes, Norberto P.
dos Santos, Wagner F.
NEUROSCIENCE LETTERS, 2013, 543 : 12 - 16

← 1 →