Development of one-pot three component reaction for the synthesis of N′-aryl-N-cyanoformamidines, essential precursors of formamidine pesticides family

被引：6

作者：

De Nino, Antonio ^{[1
]}

Maiuolo, Loredana ^{[1
]}

Nardi, Monica ^{[1
]}

Pasceri, Raffaele ^{[2
]}

Procopio, Antonio ^{[2
]}

Russo, Beatrice ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Chim, I-87030 Arcavacata Di Rende, CS, Italy

[2] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Germaneto, CZ, Italy

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷 / 01期

关键词：

Cyanoformamidines; Pesticides; One-pot reaction; Labelled compounds; TANDEM MASS-SPECTROMETRY; ORGANIC-CHEMISTRY; ISOTOPE-DILUTION; AMITRAZ; DESIGN; FUTURE; ASSAY;

D O I：

10.1016/j.arabjc.2015.06.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient one-pot three component reaction of aniline derivatives with cyanoamide and triethyl orthoformate at reflux in toluene affords N'-aryl-N-cyanoformamidines in high yields just by the distillation of the azeotrope toluene/ethyl alcohol. Labelled d(9)-Amitraz is prepared by the application of this procedure in the synthesis of formamidine pesticides family. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

收藏

页码：32 / 37

页数：6

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