AGEN2373 IS A CD137 AGONIST ANTIBODY DESIGNED TO LEVERAGE OPTIMAL CD137 AND FCγR CO-TARGETING TO PROMOTE ANTITUMOR IMMUNOLOGIC EFFECTS

被引：7

作者：

Galand, Claire ^{[1
]}

Venkatraman, Vignesh ^{[1
]}

Marques, Marilyn ^{[1
]}

Strauss, James ^{[2
]}

Carvajal, Richard ^{[3
]}

Lim, Min ^{[1
]}

Morin, Benjamin ^{[1
]}

Ignatovich, Olga ^{[1
]}

Findeis, Mark ^{[1
]}

Underwood, Dennis ^{[1
]}

Van Dijk, Marc ^{[4
]}

Shapiro, Irina ^{[1
]}

Ohanjanian, Lernik ^{[1
]}

Wijatyk, Anna ^{[1
]}

Wilson, Nicholas ^{[5
]}

Buell, Jennifer ^{[1
]}

Chand, Dhan ^{[1
]}

Savitsky, David ^{[1
]}

Tolcher, Anthony ^{[6
]}

机构：

[1] Agenus Inc, Lexington, MA USA

[2] Mary Crowley Canc Res Ctr, Dallas, TX USA

[3] Columbia Univ, Med Ctr, New York, NY USA

[4] AgenTus Therapeut Inc, Cambridge, England

[5] Gilead Sci, San Carlos, CA USA

[6] Next Onocl, San Antonio, TX USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2020年 / 8卷

关键词：

4-1BB LIGAND;

D O I：

10.1136/jitc-2020-SITC2020.0377

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

377

引用

页码：A229 / A230

页数：2

共 7 条

[1] Activation of 4-1BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway [J].

Bartkowiak, Todd ;

Jaiswal, Ashvin R. ;

Ager, Casey R. ;

Chin, Renee ;

Chen, Chao-Hsien ;

Budhani, Pratha ;

Ai, Midan ;

Reilley, Matthew J. ;

Sebastian, Manu M. ;

Hong, David S. ;

Curran, Michael A. .

CLINICAL CANCER RESEARCH, 2018, 24 (05) :1138-1151

[2] Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier [J].

Bitra, Aruna ;

Doukov, Tzanko ;

Croft, Michael ;

Zajonc, Dirk M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (26) :9958-9969

[3] Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab [J].

Li, Yan ;

Tan, Shuguang ;

Zhang, Chang ;

Chai, Yan ;

He, Mengnan ;

Zhang, Catherine W-H ;

Wang, Qihui ;

Tong, Zhou ;

Liu, Kefang ;

Lei, Yifan ;

Liu, William J. ;

Liu, Yingxia ;

Tian, Zhigang ;

Cao, Xuetao ;

Yan, Jinghua ;

Qi, Jianxun ;

Tien, Po ;

Gao, Shan ;

Gao, George F. .

CELL REPORTS, 2018, 25 (04) :909-+

[4] GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology [J].

Lin, Gloria H. Y. ;

Snell, Laura M. ;

Wortzman, Michael E. ;

Clouthier, Derek L. ;

Watts, Tania H. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (09) :4627-4639

[5] Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer [J].

Segal, Neil H. ;

He, Aiwu R. ;

Doi, Toshihiko ;

Levy, Ronald ;

Bhatia, Shailender ;

Pishvaian, Michael J. ;

Cesari, Rossano ;

Chen, Ying ;

Davis, Craig B. ;

Huang, Bo ;

Thall, Aron D. ;

Gopal, Ajay K. .

CLINICAL CANCER RESEARCH, 2018, 24 (08) :1816-1823

[6] Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody [J].

Segal, Neil H. ;

Logan, Theodore F. ;

Hodi, F. Stephen ;

McDermott, David ;

Melero, Ignacio ;

Hamid, Omid ;

Schmidt, Henrik ;

Robert, Caroline ;

Chiarion-Sileni, Vanna ;

Ascierto, Paolo A. ;

Maio, Michele ;

Urba, Walter J. ;

Gangadhar, Tara C. ;

Suryawanshi, Satyendra ;

Neely, Jaclyn ;

Jure-Kunkel, Maria ;

Krishnan, Suba ;

Kohrt, Holbrook ;

Sznol, Mario ;

Levy, Ronald .

CLINICAL CANCER RESEARCH, 2017, 23 (08) :1929-1936

[7] 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function [J].

Wen, T ;

Bukczynski, J ;

Watts, TH .

JOURNAL OF IMMUNOLOGY, 2002, 168 (10) :4897-4906

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