The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus

被引：40
作者：
Fukushima, T
Shimazoe, T
Shibata, S
Watanabe, A
Ono, M
Hamada, T
Watanabe, S
机构：
[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81282,JAPAN
[2] WASEDA UNIV,SCH HUMAN SCI,DEPT PHARMACOL,TOKOROZAWA,SAITAMA,JAPAN
来源：
NEUROSCIENCE LETTERS | 1997年 / 227卷 / 01期
关键词：
calmodulin; Ca2+/calmodulin-dependent protein kinase II; circadian rhythm; photic entrainment; suprachiasmatic nucleus;
D O I：
10.1016/S0304-3940(97)00297-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the photic entrainment of circadian rhythms using calmodulin inhibitors such as calmidazolium (CMZ) and trifluoperazine (TFP), and a CaMKII inhibitor, KN-62, in rats. Fos expression in the suprachiasmatic nucleus (SCN) of rats induced by photic stimulation (300 lux, 1 h) during the early subjective night of the rats was inhibited by treatment with CMZ (10 mg/kg i.p.) or TFP (20 mg/kg i.p.) 30 min before photic stimulation. With respect to the neuronal firing rate in the rat SCN slice, KN-62 and CMZ application during the early subjective night attenuated the glutamate (10 mu M)-induced phase shift. The present results suggest that calmodulin and CaMKII are involved in the photic entrainment mechanism in the rodent SCN. (C) 1997 Elsevier Science Ireland Ltd.
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收藏
页码：45 / 48
页数：4
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